Zaslavskaia R M, Dorbaeva D E, Teĭblium M M
Ter Arkh. 2000;72(9):21-3.
To study time-dependent effects of altiazem PP-180 and its influence on circadian pattern of hemodynamics in patients with essential hypertension stage II in its administration in 8.00, 14.00 and 22.00.
30 patients with essential hypertension stage II (mean age 63.3 years) were divided into 3 groups 10 patients each by time of altiazem intake: 8.00, 14.00 or 22.00. Altiazem was given in a single daily dose 180 mg for 10 days. Before and after the treatment, a circadian profile of arterial pressure according to Korotkov was determined, 24-h monitoring of arterial pressure was made (AP-monitor Astrakard, Russia) and echo-CG measurements of hemodynamics were made (Toshiba, Japan). Tetrapolar chest rheography was also performed.
More potent hypotensive effect of altiazem was observed in its administration in 8.00 and 22.00, less potent in 14.00. Negative chronotropic and positive inotropic effects occurred in its morning intake. These effects are less prominent in the evening and minimal if taken in 14.00. Normalization of circadian hemodynamic rhythms was registered in altiazem intake only in the morning.
Altiazem PP-180 produces time-related hemodynamic effects.
研究阿替洛尔PP - 180在上午8点、下午2点和晚上10点给药时对II期原发性高血压患者血流动力学昼夜模式的时间依赖性影响及其作用。
30例II期原发性高血压患者（平均年龄63.3岁）按阿替洛尔服药时间分为3组，每组10例：上午8点、下午2点或晚上10点。阿替洛尔每日单次剂量180mg，给药10天。治疗前后，根据柯氏音测定动脉压的昼夜变化，进行24小时动脉压监测（俄罗斯Astrakard动脉压监测仪），并进行血流动力学的超声心动图测量（日本东芝）。还进行了四极胸血流图检查。
阿替洛尔在上午8点和晚上10点给药时降压效果更强，下午2点给药时效果较弱。早晨服药会出现负性变时和正性变力作用。这些作用在晚上不那么明显，下午2点服药时最小。仅早晨服用阿替洛尔时可使昼夜血流动力学节律恢复正常。
阿替洛尔PP - 180产生与时间相关的血流动力学效应。
