钩枝藤碱A - C：来自钩枝藤的新型5,8'-偶联萘基异喹啉生物碱
Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko.
作者信息
Bringmann G, Günther C, Saeb W, Mies J, Wickramasinghe A, Mudogo V, Brun R
机构信息
Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany, Department of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka.
出版信息
J Nat Prod. 2000 Oct;63(10):1333-7. doi: 10.1021/np000199t.
Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.
从镰花血藤中分离并确定了三种新的萘基异喹啉生物碱，镰花血藤碱A-C（1-3），以及已知化合物柯鲁平胺A（4）。它们的5,8'-偶合表明镰花血藤与其他中非血藤属物种有密切的生源关系。在体外针对恶性疟原虫的NF54和K1菌株进行评估时，化合物1-4表现出良好到中等的抗疟活性。
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