[门腔分流术后全结肠切除术和肠道灭菌效果的新评估]
[New evaluation of effect of total colectomy and intestinal sterilization following portacaval shunt].
作者信息
Funovics J, James J H, Keane J M, Wesdorp R I, Fischer J E
出版信息
Langenbecks Arch Chir. 1975;Suppl:13-7.
The effect of total colectomy and "intestinal sterilisation" following chronic portocaval shunt was investigated in 96 Sprague-Dawley rats: while both therapeutic procedures are of no significant impact on serum ammonia concentrations there is a significant reduction of brain octopamine, a known false neuro-chemical transmitter, and a clear response on aromatic amino acid levels in brain and plasma. The interference with central and peripheral neurotransmitters is suggested as an alternative mechanism in experimental encephalopathy.
对96只斯普拉格-道利大鼠研究了慢性门腔分流术后全结肠切除术和“肠道除菌”的效果：虽然这两种治疗方法对血清氨浓度均无显著影响，但脑内章鱼胺（一种已知的假性神经化学递质）显著减少，且脑和血浆中的芳香族氨基酸水平有明显变化。实验性脑病的另一种机制提示为对中枢和外周神经递质的干扰。
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