Paschke T
Analytisch-Biologisches Forschungslabor, Goethestrasse 20, D-80336 Munich, Germany.
Mutagenesis. 2000 Nov;15(6):457-8. doi: 10.1093/mutage/15.6.457.
Analysis of the IARC p53 database revealed a large number of discrepancies in the classification of smoking status for identical lung cancer entries in different versions of the database. In addition, no statistically significant differences in G-->T transversion mutation frequencies or in mutational hotspots at codons 157, 248 and 273 were found in the R3 version of the database between p53 sequences from smoking and non-smoking lung cancer patients. The possible influence of confounding factors on p53 mutation spectra was demonstrated as illustrated by the impact of ethnicity on G-->T transversion mutation frequencies.
对国际癌症研究机构（IARC）的p53数据库进行分析后发现，在该数据库不同版本中，相同肺癌条目的吸烟状态分类存在大量差异。此外，在数据库的R3版本中，吸烟与非吸烟肺癌患者的p53序列之间，未发现G→T颠换突变频率或157、248和273密码子处突变热点有统计学上的显著差异。种族对G→T颠换突变频率的影响表明了混杂因素对p53突变谱可能产生的影响。
