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抑郁和焦虑是否能预测心肌梗死后12个月的冠状动脉事件复发?

Do depression and anxiety predict recurrent coronary events 12 months after myocardial infarction?

作者信息

Lane D, Carroll D, Ring C, Beevers D G, Lip G Y

机构信息

School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK.

出版信息

QJM. 2000 Nov;93(11):739-44. doi: 10.1093/qjmed/93.11.739.

Abstract

We examined the association between depression and anxiety and recurrent coronary heart disease events during the first 12 months subsequent to myocardial infarction. The Beck Depression Inventory and the State-Trait Anxiety Inventory were completed during hospitalization by 288 myocardial infarction patients. Peel Index score and Killip class were used as indices of disease severity. The 12-month incidence of recurrent coronary heart disease events (fatal and non-fatal) was determined. Eighty-two patients experienced recurrent coronary heart disease events, including 27 cardiac fatalities, during follow-up. Whereas the Peel Index differentiated patients who experienced recurrent events from those who did not (OR 3.00, 95% CI 1.46-6.20), symptoms of depression (OR 0.97, 95% CI 0. 55-1.70) and anxiety (OR 1.00, 95% CI 0.98-1.02) were unrelated to outcome. Depression and anxiety did not predict subsequent coronary heart disease events and were not associated with either Peel Index scores or Killip class.

摘要

我们研究了心肌梗死后最初12个月内抑郁症、焦虑症与冠心病复发事件之间的关联。288名心肌梗死患者在住院期间完成了贝克抑郁量表和状态-特质焦虑量表。皮尔指数评分和Killip分级被用作疾病严重程度的指标。确定了冠心病复发事件(致命和非致命)的12个月发生率。在随访期间,82名患者发生了冠心病复发事件,其中包括27例心源性死亡。虽然皮尔指数能够区分发生复发事件的患者和未发生复发事件的患者(比值比3.00,95%置信区间1.46 - 6.20),但抑郁症状(比值比0.97,95%置信区间0.55 - 1.70)和焦虑症状(比值比1.00,95%置信区间0.98 - 1.02)与结果无关。抑郁和焦虑不能预测随后的冠心病事件,且与皮尔指数评分或Killip分级均无关联。

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