Umeda M, Komatsubara H, Nishimatsu N, Yokoo S, Shibuya Y, Komori T
Department of Oral and Maxillofacial Surgery, Kobe University School of Medicine, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Nov;90(5):667-70. doi: 10.1067/moe.2000.110087.
This retrospective clinical study evaluated the usefulness of high-dose rate (HDR) brachytherapy for stage I-II tongue cancer in comparison with traditional low-dose rate (LDR) brachytherapy.
Twenty-five patients with stage I-II tongue cancer underwent HDR between 1995 and 1999. The status of local control and late neck metastasis, survival rate, and frequency of osteonecrosis in these patients were examined in comparison with a historical control made up of 71 patients who underwent LDR between 1980 and 1995.
The local control rate and survival rate were lower in the HDR group than in the LDR group. There were no apparent differences in the frequency of late neck metastasis between the two groups. Osteonecrosis occurred earlier and more frequently in the HDR group.
We would caution the use of HDR brachytherapy until further studies are done in many institutions.
本回顾性临床研究评估了高剂量率（HDR）近距离放射治疗与传统低剂量率（LDR）近距离放射治疗相比，对I-II期舌癌的有效性。
1995年至1999年间，25例I-II期舌癌患者接受了高剂量率近距离放射治疗。将这些患者的局部控制情况、颈部晚期转移情况、生存率和骨坏死发生率与1980年至1995年间接受低剂量率近距离放射治疗的71例患者组成的历史对照组进行比较。
高剂量率组的局部控制率和生存率低于低剂量率组。两组颈部晚期转移发生率无明显差异。高剂量率组骨坏死出现得更早且更频繁。
在许多机构进行进一步研究之前，我们建议谨慎使用高剂量率近距离放射治疗。
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