Morse A N, Whitaker M D
Department of Obstetrics and Gynecology, Mayo Clinic Scottsdale, Arizona 85259, USA.
J Reprod Med. 2000 Oct;45(10):850-2.
Lipoatrophic diabetes mellitus is a rare insulin-resistance syndrome. A successful pregnancy occurred in a woman with lipoatrophic diabetes with no antepartum or intrapartum complications except hypertriglyceridemia, treated with gemfibrozil.
A 29-year-old primigravida had lipoatrophic diabetes most consistent with congenital partial lipodystrophy (Kobberling-Dunnigan syndrome). The antenatal course was remarkable only for a midtrimester rise in serum triglycerides. The patient underwent oxytocin induction and an uncomplicated vaginal delivery.
This case demonstrates that women with lipoatrophic diabetes who are otherwise healthy should not be discouraged from trying to conceive. Blood lipids should be checked periodically and hypertriglyceridemia treated to prevent pancreatitis. Gemfibrozil was used in this patient without apparent adverse effects.
脂肪萎缩性糖尿病是一种罕见的胰岛素抵抗综合征。一名患有脂肪萎缩性糖尿病的女性成功怀孕，除高甘油三酯血症外无产前或产时并发症，接受吉非贝齐治疗。
一名29岁初产妇患有与先天性部分脂肪营养不良（科伯林-邓尼根综合征）最为相符的脂肪萎缩性糖尿病。孕期过程仅在孕中期血清甘油三酯升高方面较为显著。患者接受催产素引产并顺利经阴道分娩。
该病例表明，身体健康的脂肪萎缩性糖尿病女性不应被劝阻尝试怀孕。应定期检查血脂并治疗高甘油三酯血症以预防胰腺炎。该患者使用吉非贝齐未出现明显不良反应。
