作为亲骨物质的钐-153丙二胺四亚甲基膦酸酯（PDTMP）配合物的制备及稳定性研究
Studies on the preparation and stability of samarium-153 propylene diamine tetramethylene phosphonate (PDTMP) complex as a bone seeker.
作者信息
Majali M A, Mathakar A R, Shimpi H H, Banerjee S, Samuel G
机构信息
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India.
出版信息
Appl Radiat Isot. 2000 Dec;53(6):987-91. doi: 10.1016/s0969-8043(99)00270-5.
Propylene diamine tetra methylene phosphonate (PDTMP) was synthesised by modifying a method reported for the synthesis of EDTMP. Complexation of the synthesised phosphonate ligand with 153Sm was carried out by varying the experimental parameters and the complex was radiochemically characterized. Biodistribution studies showed that the uptake by bone in rats was 2% per g of bone, which was retained upto 48 h. The uptake by other organs was insignificant, except by the liver which showed a slightly higher absorption.
通过改进报道的乙二胺四亚甲基膦酸（EDTMP）合成方法合成了丙二胺四亚甲基膦酸（PDTMP）。通过改变实验参数，使合成的膦酸配体与¹⁵³Sm络合，并对该络合物进行了放射化学表征。生物分布研究表明，大鼠骨骼对其摄取量为每克骨骼2%，并可保留长达48小时。除肝脏显示出略高的吸收外，其他器官的摄取量微不足道。
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