Rajendran V, Prakash K R, Ved H S, Saxena A, Doctor B P, Kozikowski A P
Department of Neurology, Georgetown University Medical Center, Washington, DC 20007-2197, USA.
Bioorg Med Chem Lett. 2000 Nov 6;10(21):2467-9. doi: 10.1016/s0960-894x(00)00494-7.
(+/-)-10,10-Dimethylhuperzine A (2, DMHA) has been synthesized, and its enantiomers have been separated using chiral HPLC. (-)-DMHA inhibits AChE with a Ki value approaching that of (-)-huperzine A, whereas (+)-DMHA shows no AChE inhibitory activity. On the other hand, both enantiomers are equally potent against glutamate-induced neurotoxicity when tested in neurons.
