Dougall D S, Lamousé-Smith E S, McCarthy S A
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15213, USA.
Cell Immunol. 2000 Oct 10;205(1):1-12. doi: 10.1006/cimm.2000.1709.
We recently reported that the in vivo development of a novel CD8(+), but anti-CD8 mAb-resistant, CTL population is complex and distinct from that of conventional anti-CD8 mAb-sensitive CD8(+) CTL. In this study, we explored the role of the thymus in the generation of anti-CD8-resistant pCTL and in their maintenance once they are generated. We also investigated the capacities of the adult periphery and thymus to support the regeneration of anti-CD8-resistant pCTL after peripheral lymphocyte and/or thymocyte depletion. These studies indicate that the thymus is necessary for the generation but not the maintenance of peripheral anti-CD8-resistant pCTL. These studies also indicate that the adult thymus can produce these pCTL and the adult periphery can support their regeneration, if a new wave of thymic maturation is experimentally induced. These results may have implications for immune reconstitution after treatment for cancer or HIV infection.
我们最近报道，一种新型的CD8(+)但抗CD8单克隆抗体耐药的CTL群体在体内的发育过程较为复杂，且与传统的抗CD8单克隆抗体敏感的CD8(+) CTL不同。在本研究中，我们探讨了胸腺在抗CD8耐药pCTL产生过程中的作用以及它们产生后的维持机制。我们还研究了成年外周组织和胸腺在淋巴细胞和/或胸腺细胞耗竭后支持抗CD8耐药pCTL再生的能力。这些研究表明，胸腺对于外周抗CD8耐药pCTL的产生是必需的，但对于其维持并非必需。这些研究还表明，如果通过实验诱导新一轮的胸腺成熟，成年胸腺能够产生这些pCTL，成年外周组织能够支持它们的再生。这些结果可能对癌症或HIV感染治疗后的免疫重建具有重要意义。
