遗传性非息肉病性结直肠癌：最新综述
Hereditary non-polyposis colorectal cancer: an updated review.
作者信息
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder J B
机构信息
Department of Surgery, North Manchester General Hospital, Manchester, UK.
出版信息
Eur J Surg Oncol. 2000 Nov;26(7):635-45. doi: 10.1053/ejso.2000.0974.
INTRODUCTION
Colorectal cancer is the commonest cause of death due to malignancy in non-smokers in the western countries. The two main hereditary types of colorectal cancer are familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), constituting approximately 10% of all cases of colorectal cancer. The main aim of this review is to reappraise the current advances in the genetics and diagnosis of HNPCC.
METHODS
A Medline search was carried out to identify papers published from 1970 to 1999 on HNPCC. Embase and Cochrane databases were also searched. Reference lists of retrieved articles were carefully searched for additional articles.
RESULTS AND CONCLUSIONS
Recent technological advances in the genetics of HNPCC have refined the criteria for diagnosis and management of HNPCC, however current policies regarding the testing of pedigrees are not clearly established. We believe that with the rapid development in this area definitive clinical guidelines will need to be available in future for the management of HNPCC.
引言
在西方国家，结直肠癌是不吸烟者因恶性肿瘤死亡的最常见原因。结直肠癌的两种主要遗传类型是家族性腺瘤性息肉病（FAP）和遗传性非息肉病性结直肠癌（HNPCC），约占所有结直肠癌病例的10%。本综述的主要目的是重新评估HNPCC在遗传学和诊断方面的当前进展。
方法
进行了一项Medline检索，以识别1970年至1999年发表的关于HNPCC的论文。还检索了Embase和Cochrane数据库。仔细搜索了检索文章的参考文献列表以获取其他文章。
结果与结论
HNPCC遗传学方面的最新技术进展完善了HNPCC的诊断和管理标准，然而目前关于家系检测的政策尚未明确确立。我们认为，随着该领域的快速发展，未来需要有明确的临床指南来管理HNPCC。
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