Wiernik P H, Hu X, Ratech H, Fineberg S, Marino P, Schleider M A, Etkind P, Walewski J A
OLM Comprehensive Cancer Center, New York Medical College, Bronx 10466, USA.
Cancer J. 2000 Sep-Oct;6(5):336-42.
The purpose of this study was to describe a series of patients with breast cancer and non-Hodgkin's lymphoma and to determine the usual sequence of the diagnoses. Therapy for both neoplasms and its relationship to the development of the second neoplasm were also evaluated.
Patients were identified primarily from cancer registries at various institutions. The observed proportion of women diagnosed with breast cancer first, after, or simultaneously with non-Hodgkin's lymphoma was compared with the expected proportion by employing New York State and Surveillance, Epidemiology, and End Results program cancer incidence rates.
The expected number of lymphoma cases that were diagnosed after or simultaneously with breast cancer was 31.6 (New York state data) to 39.1 (New York State and Surveillance, Epidemiology, and End Results data), and 78 such cases were identified from a total group of 87 (P < or = .001). There was no evidence that in this study, lymphoma as a second neoplasm was therapy induced.
Anecdotal case reports suggest a relationship between breast cancer and non-Hodgkin's lymphoma. Mouse mammary tumor virus induces breast cancer and, in some circumstances, lymphoma in mice. The mouse mammary tumor virus ENV gene has been identified in approximately one third of human breast cancers. Women with both breast cancer and lymphoma are diagnosed first with breast cancer or simultaneously with both cancers more frequently than expected, and the lymphoma is not therapy induced. In some women with both breast cancer and lymphoma, the two neoplasms may have a common etiology, perhaps viral.
本研究旨在描述一系列乳腺癌和非霍奇金淋巴瘤患者，并确定诊断的通常顺序。同时还评估了两种肿瘤的治疗方法及其与第二种肿瘤发生发展的关系。
主要从各机构的癌症登记处识别患者。通过采用纽约州以及监测、流行病学和最终结果计划的癌症发病率，将首次诊断为乳腺癌后、同时或之后诊断为非霍奇金淋巴瘤的女性观察比例与预期比例进行比较。
在乳腺癌之后或同时诊断为淋巴瘤的预期病例数为31.6例（纽约州数据）至39.1例（纽约州及监测、流行病学和最终结果数据），在总共87例患者中识别出78例此类病例（P≤0.001）。本研究中没有证据表明作为第二种肿瘤的淋巴瘤是由治疗引起的。
轶事病例报告表明乳腺癌与非霍奇金淋巴瘤之间存在关联。小鼠乳腺肿瘤病毒可诱发小鼠乳腺癌，在某些情况下还可诱发淋巴瘤。在大约三分之一的人类乳腺癌中已鉴定出小鼠乳腺肿瘤病毒ENV基因。同时患有乳腺癌和淋巴瘤的女性首先被诊断为乳腺癌或同时被诊断为两种癌症的频率高于预期，且淋巴瘤不是由治疗引起的。在一些同时患有乳腺癌和淋巴瘤的女性中，这两种肿瘤可能有共同的病因，可能是病毒。
