Hibino N, Tomino T, Satoh H, Hamawaki M, Imura M, Suzuki T, Inukai M
Department of Cardiovascular Surgery, Ehime Prefecture Central Hospital, Matsuyama, Japan.
Kyobu Geka. 2000 Nov;53(12):1019-23.
We investigated the effect of milrinone (phoshphodiesterase III inhibitor) on postoperative hemodynamics in adult eighteen cardiac surgical patients (mean LVEF = 63%). Milrinone was administrated just after the aortic declamping during CPB. Comparing with control group, systemic vascular resistance decreased significantly and sufficient inotropic effect was sustained. In order to keep proper blood pressure much more cathechoramine dose was need when milrinone dose increased during this study. This is supposed that milrinone affected strong vasodilating effect and caused relative hypovolemic condition to the patient who showed good cardiac function. Milrinone causes best efficacy to the patient of poor cardiac function when he showed deconpensation or relatively hypervolemic hemodynamic condition.
我们研究了米力农（磷酸二酯酶III抑制剂）对18例成年心脏手术患者（平均左心室射血分数=63%）术后血流动力学的影响。米力农在体外循环期间主动脉钳夹松开后立即给药。与对照组相比，全身血管阻力显著降低，且维持了足够的正性肌力作用。在本研究中，当米力农剂量增加时，为维持适当血压需要更多的儿茶酚胺剂量。这可能是因为米力农具有较强的血管舒张作用，导致心功能良好的患者出现相对血容量不足的情况。当心功能差的患者出现失代偿或相对高血容量血流动力学状态时，米力农对其疗效最佳。
