de la Fuente-Fernández R
Division of Neurology, Hospital A. Marcide, Ferrol, La Coruña, Spain.
Ann Neurol. 2000 Nov;48(5):782-7. doi: 10.1002/1531-8249(200011)48:5<782::aid-ana12>3.3.co;2-5.
First-degree relatives of patients with Parkinson's disease (PD) are at higher risk for PD development than first-degree relatives of control subjects, but clinical twin studies have failed to demonstrate a genetic basis in PD. It is hypothesized that maternal exposure to certain environmental factors could lead to pathological changes in the ovum that predispose to the development of PD in the child. In this study of 299 patients and 295 controls, the age at onset of PD was found to correlate negatively with maternal age at birth of patient but not with paternal age. Mothers and fathers of patients with PD had an increased risk of PD as compared with parents of control subjects. These results suggest a maternal effect on PD that could be primarily environmental in nature.
帕金森病（PD）患者的一级亲属患帕金森病的风险高于对照受试者的一级亲属，但临床双胞胎研究未能证明帕金森病存在遗传基础。据推测，母亲暴露于某些环境因素可能导致卵子发生病理变化，从而使孩子易患帕金森病。在这项对299名患者和295名对照的研究中，发现帕金森病的发病年龄与患者出生时母亲的年龄呈负相关，与父亲的年龄无关。与对照受试者的父母相比，帕金森病患者的母亲和父亲患帕金森病的风险增加。这些结果表明母亲对帕金森病有影响，其本质可能主要是环境因素。
