Curry D L, Bennett L L
Proc Natl Acad Sci U S A. 1976 Jan;73(1):248-51. doi: 10.1073/pnas.73.1.248.
Somatostatin, the hypothalamic growth hormone release inhibitory factor (GHRIF), directly inhibits both the first and second phases of insulin secretion. The sensitivities of these two phases of insulin secretion to somatostatin differ remarkably. The first phase of secretion is approximately 25 to 50 times more sensitive to somatostatin inhibition than is the second phase. In addition, somatostatin inhibition of insulin secretion during the second phase is "reversed" by supplemental calcium, whereas the somatostatin effect on the first phase is unaffected by additional calcium. These findings suggest that the cellular events which produce the two phases of insulin secretion are separate processes, and that somatostatin has a dual mechanism of action in inhibiting insulin secretion.
生长抑素，即下丘脑生长激素释放抑制因子（GHRIF），可直接抑制胰岛素分泌的第一相和第二相。胰岛素分泌的这两个阶段对生长抑素的敏感性差异显著。分泌的第一相比第二相对生长抑素抑制作用的敏感性高约25至50倍。此外，在第二阶段，补充钙可“逆转”生长抑素对胰岛素分泌的抑制作用，而生长抑素对第一阶段的作用不受额外钙的影响。这些发现表明，产生胰岛素分泌两个阶段的细胞事件是独立的过程，并且生长抑素在抑制胰岛素分泌方面具有双重作用机制。
