Warashina M, Kuwabara T, Taira K
National Institute for Advanced Interdisciplinary Research AIST, MITI 305-8562, Tsukuba Science City, Japan.
Structure. 2000 Nov 15;8(11):R207-12. doi: 10.1016/s0969-2126(00)00517-7.
The appropriate folding of catalytic RNA is a prerequisite for effective catalysis. A novel ribozyme, the maxizyme, has been generated and its activity can be controlled allosterically. The maxizymes work both in vitro and in vivo indicating the potential utility of this novel class of ribozyme as a gene-inactivating agent with a biosensor function.
催化性RNA的正确折叠是有效催化的前提条件。一种新型核酶——最大酶已被研制出来，其活性可通过别构作用进行控制。最大酶在体外和体内均能发挥作用，这表明这类新型核酶作为一种具有生物传感器功能的基因失活剂具有潜在的应用价值。
