Kably Ambe A, Barrón Vallejo J, Fernández Castro M, Karchmer Krivitzky S
Centro Especializado para la Atención de la Muje, Hospital Angeles de las Lomas.
Ginecol Obstet Mex. 2000 Sep;68:363-7.
The objective was to evaluate if the preovulatory molecular ratio between progesterone and estradiol has age-dependent changes in patients undergone controlled ovarian hyperstimulation. Were studied 180 cycles of conventional in vitro fertilization. Patients were divided in three groups: Group 1 (age less than 30 years; n = 40), group 2 (age between 30 and 35 years; n = 82), and group 3 (age between 36 and 40 years; n = 58). Leuprolide acetate was used in all cases. Molecular progesterone/estradiol ratio was calculate with the following formula: [Serum progesterone (ng/mL) x 3180 (SI x 10(3) divided by serum estradiol (pg/mL) x 3.671 (SI)]. In patients with age more than 38.5 years there was positive correlation between preovulatory progesterone and estradiol (R = 0.55, R2 = 0.30). There were significant difference in molecular progesterone/estradiol ratio between group 1 compared to group 2 (P less than 0.001), group 1 compared to group 3 (P less than 0.0001), as soon as group 1 compared to group 2 plus group 3 (P less than 0.0001). It is concluded that molecular progesterone/estradiol ratio decreases before any endocrino evidence of ovarian aging. The value of this putative test of ovarian reserve is discussed.
目的是评估在接受控制性卵巢刺激的患者中，排卵前孕酮与雌二醇的分子比率是否存在年龄依赖性变化。研究了180个常规体外受精周期。患者分为三组：第1组（年龄小于30岁；n = 40），第2组（年龄在30至35岁之间；n = 82），以及第3组（年龄在36至40岁之间；n = 58）。所有病例均使用醋酸亮丙瑞林。分子孕酮/雌二醇比率通过以下公式计算：[血清孕酮（ng/mL）×3180（SI×10³）除以血清雌二醇（pg/mL）×3.671（SI）]。在年龄超过38.5岁的患者中，排卵前孕酮与雌二醇之间存在正相关（R = 0.55，R² = 0.30）。第1组与第2组相比，分子孕酮/雌二醇比率存在显著差异（P < 0.001），第1组与第3组相比（P < 0.0001），第1组与第2组加第3组相比（P < 0.0001）。结论是，在卵巢衰老的任何内分泌证据出现之前，分子孕酮/雌二醇比率就会降低。讨论了这种假定的卵巢储备测试的价值。
