Steenberghe D, Bossuyt M
Rev Stomatol Chir Maxillofac. 1975 Nov;76(7):509-25.
Two patients presenting the clinical characteristics of the "Lethal Midline Granuloma" are discussed. In the first case, the autopsy allowed the final diagnosis of a histiocytic medullary reticulosis (Robb-Smith). For the second patient the late evolution and the final biopsy gave the diagnosis of malignant reticulosis without further detail. These two cases prove that for a midface necrosis no final diagnosis can be obtained without an extensive clinical examination and autopsy material. There are numerous arguments to consider the "Lethal Midline Granuloma" as a clinical term which can cover several pathological entities. A classification is proposed.
讨论了两名具有“致死性中线肉芽肿”临床特征的患者。在第一例中,尸检最终诊断为组织细胞性髓性网状细胞增生症(罗布-史密斯病)。对于第二例患者,晚期病情发展及最终活检诊断为恶性网状细胞增生症,但无更多细节。这两例病例证明,对于面部中部坏死,若没有广泛的临床检查和尸检材料,无法得出最终诊断。有许多理由将“致死性中线肉芽肿”视为一个可涵盖多种病理实体的临床术语。本文提出了一种分类方法。