Jazieh A R, Hussain M, Howington J A, Spencer H J, Husain M, Grismer J T, Read R C
Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Ann Thorac Surg. 2000 Oct;70(4):1168-71. doi: 10.1016/s0003-4975(00)01529-0.
About one-third to one-half of patients with early stages of non-small cell lung cancer (NSCLC) succumb to their disease. In this study, we attempted to identify prognostic factors that predict outcome in patients with stages I and II NSCLC.
A retrospective evaluation of 454 patients with surgically resected stages I and II NSCLC was performed to determine the impact of various clinical, laboratory, and pathological factors on patient outcome such as overall survival (OS) and event-free survival (EFS).
Patients older than 65 years had shorter EFS and OS than younger patients (p = 0.002). Patients with preoperative hemoglobin less than or equal to 10 g% had shorter EFS and OS compared to patients with a hemoglobin greater than 10 g% (p = 0.001). Expectedly, OS and EFS were shorter in patients with stage II as compared to stage I patients (p < 0.001). In a multivariate analysis, age, hemoglobin level, and stage remain significant predictors for EFS and OS.
Older age, anemia, and higher stage are important prognostic factors in patients with surgically resected stage I and II NSCLC.
大约三分之一到二分之一的早期非小细胞肺癌（NSCLC）患者死于该疾病。在本研究中，我们试图确定预测I期和II期NSCLC患者预后的因素。
对454例接受手术切除的I期和II期NSCLC患者进行回顾性评估，以确定各种临床、实验室和病理因素对患者预后的影响，如总生存期（OS）和无事件生存期（EFS）。
65岁以上患者的EFS和OS比年轻患者短（p = 0.002）。术前血红蛋白小于或等于10 g%的患者与血红蛋白大于10 g%的患者相比，EFS和OS较短（p = 0.001）。不出所料，II期患者的OS和EFS比I期患者短（p < 0.001）。在多变量分析中，年龄、血红蛋白水平和分期仍然是EFS和OS的重要预测因素。
年龄较大、贫血和分期较高是接受手术切除的I期和II期NSCLC患者的重要预后因素。
