手术切除的Ⅰ期和Ⅱ期非小细胞肺癌患者的预后因素
Prognostic factors in patients with surgically resected stages I and II non-small cell lung cancer.
作者信息
Jazieh A R, Hussain M, Howington J A, Spencer H J, Husain M, Grismer J T, Read R C
机构信息
Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
出版信息
Ann Thorac Surg. 2000 Oct;70(4):1168-71. doi: 10.1016/s0003-4975(00)01529-0.
BACKGROUND
About one-third to one-half of patients with early stages of non-small cell lung cancer (NSCLC) succumb to their disease. In this study, we attempted to identify prognostic factors that predict outcome in patients with stages I and II NSCLC.
METHODS
A retrospective evaluation of 454 patients with surgically resected stages I and II NSCLC was performed to determine the impact of various clinical, laboratory, and pathological factors on patient outcome such as overall survival (OS) and event-free survival (EFS).
RESULTS
Patients older than 65 years had shorter EFS and OS than younger patients (p = 0.002). Patients with preoperative hemoglobin less than or equal to 10 g% had shorter EFS and OS compared to patients with a hemoglobin greater than 10 g% (p = 0.001). Expectedly, OS and EFS were shorter in patients with stage II as compared to stage I patients (p < 0.001). In a multivariate analysis, age, hemoglobin level, and stage remain significant predictors for EFS and OS.
CONCLUSIONS
Older age, anemia, and higher stage are important prognostic factors in patients with surgically resected stage I and II NSCLC.
背景
大约三分之一到二分之一的早期非小细胞肺癌（NSCLC）患者死于该疾病。在本研究中，我们试图确定预测I期和II期NSCLC患者预后的因素。
方法
对454例接受手术切除的I期和II期NSCLC患者进行回顾性评估，以确定各种临床、实验室和病理因素对患者预后的影响，如总生存期（OS）和无事件生存期（EFS）。
结果
65岁以上患者的EFS和OS比年轻患者短（p = 0.002）。术前血红蛋白小于或等于10 g%的患者与血红蛋白大于10 g%的患者相比，EFS和OS较短（p = 0.001）。不出所料，II期患者的OS和EFS比I期患者短（p < 0.001）。在多变量分析中，年龄、血红蛋白水平和分期仍然是EFS和OS的重要预测因素。
结论
年龄较大、贫血和分期较高是接受手术切除的I期和II期NSCLC患者的重要预后因素。
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