C(3)苯并呋喃衍生的双芳基季铵中心的合成：重氮酰胺A的合成方法。

Synthesis of C(3) benzofuran-derived bisaryl quaternary centers: approaches to diazonamide A.

作者信息

Fuerst D E, Stoltz B M, Wood J L

机构信息

Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

出版信息

Org Lett. 2000 Nov 2;2(22):3521-3. doi: 10.1021/ol006578v.

DOI:10.1021/ol006578v

PMID:11082024

Abstract

[reaction: see text] Two complementary strategies for the synthesis of the diazonamide A bisaryl quaternary center are described. The first strategy relies upon an extremely facile tandem cyclopropanation/ring-opening sequence, which has proven amenable to chiral catalysis to provide enantioenriched material. The second strategy relies upon a more concise alkylation route ideal for material advancement.

摘要

[反应：见正文] 描述了两种用于合成重氮酰胺A双芳基季中心的互补策略。第一种策略依赖于极其简便的串联环丙烷化/开环序列，该序列已被证明适用于手性催化以提供对映体富集的材料。第二种策略依赖于更简洁的烷基化路线，这对于材料开发是理想的。