State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Org Lett. 2010 Oct 15;12(20):4458-61. doi: 10.1021/ol101396n.
Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.
阿佐那嗪，一种独特的六元环二肽，从夏威夷海洋沉积物来源的真菌 Aspergillus insulicola 中分离得到。其绝对构型，2R,10R,11S,19R，是通过 NMR、HRESIMS 和 CD 数据以及分子模型的见解确定的。提出了一种可能的生物合成途径，并针对癌细胞系和 NFκB 抑制测定法研究了其生物学特性。
