Wagener C, Ergün S
Department of Clinical Chemistry, Institute of Anatomy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, Hamburg, D-20251, Germany.
Exp Cell Res. 2000 Nov 25;261(1):19-24. doi: 10.1006/excr.2000.5038.
The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a member of the immunoglobulin superfamily, is expressed in microvessels of proliferating tissues such as endometrium, in tissues after wounding, and in solid human tumors. In microvascular human endothelial cells, purified native and recombinant CEACAM1 stimulates proliferation, chemotaxis, and tube formation. In the chorioallantoic membrane of the chicken, CEACAM1 induces angiogenesis. The angiogenic effects of CEACAM1 are additive to those of the vascular endothelial growth factor (VEGF). The expression of CEACAM1 is up-regulated by VEGF, and VEGF-induced in vitro tube formation is blocked completely by a monoclonal CEACAM1 antibody. These findings indicate that CEACAM1 is an angiogenic factor and an effector of VEGF.
癌胚抗原相关细胞黏附分子1（CEACAM1）是免疫球蛋白超家族的成员，在增殖组织（如子宫内膜）的微血管、创伤后的组织以及人类实体瘤中表达。在人微血管内皮细胞中，纯化的天然和重组CEACAM1可刺激细胞增殖、趋化性和管腔形成。在鸡的绒毛尿囊膜中，CEACAM1可诱导血管生成。CEACAM1的血管生成作用与血管内皮生长因子（VEGF）的作用相加。CEACAM1的表达受VEGF上调，并且VEGF诱导的体外管腔形成被CEACAM1单克隆抗体完全阻断。这些发现表明CEACAM1是一种血管生成因子，也是VEGF的效应分子。
