Koutsavlis A T, Wolfson C
Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec.
Chronic Dis Can. 2000;21(3):93-103.
In order to identify elements of mobility that predict survival in elderly people with dementia, we conducted a two-year follow-up of a cohort of dementia subjects from the population-based Canadian Study of Health and Aging. There were 749 prevalent cases of Alzheimer's disease (AD) and 208 prevalent cases of vascular dementia. Elements of mobility that predicted death during the two-year follow-up period included difficulty in dressing (OR = 2.08, 95% CI 1.41 3.07), difficulty in getting about (OR = 1.69, 95% CI 1.18 2.40), history of falls (OR = 1.43, 95% CI 1.05 1.94), abnormal gait (OR = 1.61, 95% CI 1.08 2.40) and abnormal motor strength (OR = 1.51, 95% CI 1.07 2.15). Sociodemographic factors such as older age and male sex were also significant predictors of decreased survival. These associations are potentially useful to clinicians and health professionals by providing prognostic information to supply to families and suggesting areas in which interventions to improve survival might be focused
为了确定可预测老年痴呆症患者生存情况的活动能力要素，我们对基于人群的加拿大健康与老龄化研究中的一组痴呆症受试者进行了为期两年的随访。其中有749例阿尔茨海默病（AD）的现患病例和208例血管性痴呆的现患病例。在两年随访期内可预测死亡的活动能力要素包括穿衣困难（比值比[OR]=2.08，95%置信区间[CI]为1.41至3.07）、行动困难（OR=1.69，95%CI为1.18至2.40）、跌倒史（OR=1.43，95%CI为1.05至1.94）、步态异常（OR=1.61，95%CI为1.08至2.40）以及运动力量异常（OR=1.51，95%CI为1.07至2.15）。年龄较大和男性等社会人口学因素也是生存时间缩短的重要预测因素。这些关联对临床医生和健康专业人员可能有用，因为它们能提供预后信息以供告知家属，并提示可能聚焦改善生存情况干预措施的领域。
