Kies B M, Keeton G R
S Afr Med J. 1975 Dec 6;49(52):2151-2.
Three septicaemic patients with acute renal failure required carbenicillin. Septicaemia was caused by Pseudomonas in 2 patients and by Serratia marcescens in the third. Therapy in the first 2 patients was complicated by massive gastro-intestinal and uterine bleeding. Septicaemia in the third patient was initially uncontrolled owing to inadequate serum levels of carbenicillin, despite increased dosage as renal function improved. The problems and indications for the use of carbenicillin in renal failure are discussed and the possible relationship to bleeding diathesis is considered.
三名患有急性肾衰竭的败血症患者需要使用羧苄青霉素。两名患者的败血症由铜绿假单胞菌引起，第三名患者的败血症由粘质沙雷氏菌引起。前两名患者的治疗因严重的胃肠道和子宫出血而变得复杂。第三名患者的败血症最初未得到控制，尽管随着肾功能改善增加了羧苄青霉素的剂量，但血清中羧苄青霉素水平仍不足。本文讨论了肾衰竭患者使用羧苄青霉素的问题和适应症，并考虑了其与出血素质的可能关系。
