Barcz E, Kamiński P, Marianowski L
I Katedry i Kliniki Połoznictwa i Ginekologii AM w Warszawie.
Ginekol Pol. 2000 Sep;71(9):993-1000.
The theory of Sampson that endometrial cells and fragments desquamated during the menstrual period are transported through fallopian tubes into the peritoneal cavity where they implant, proliferate and develop into endometriotic lesions is generally accepted. Accumulating data suggest that deficient immunity against retrograde endometrium during menstruation may be involved in the pathophysiology of endometriosis. Recent studies in women with endometriosis demonstrated functional changes in several immunologic components in the peritoneal fluid as well as in sera of those patients. Among others it was shown that a wild pattern of cytokines take part in events occurring during endometrial cells implantation, proliferation and forming of endometriotic lesions. One of them VEGF seems to play a very important role in neovascularisation and implantation of ectopic endometrial lesions. In present study we evaluated the concentrations of VEGF in serum of patients with endometriosis and showed negative correlation between AFS score and VEGF concentration in peritoneal endometriosis. Above results do not confirm former observations indicating the role of VEGF in endometriosis pathogenesis.
桑普森提出的理论认为，月经期间脱落的子宫内膜细胞和碎片通过输卵管进入腹腔并在那里着床、增殖，进而发展为子宫内膜异位症病变，这一理论已被广泛接受。越来越多的数据表明，月经期间对逆行子宫内膜的免疫缺陷可能与子宫内膜异位症的病理生理过程有关。最近针对子宫内膜异位症女性患者的研究表明，这些患者的腹腔液以及血清中的多种免疫成分出现了功能变化。其中发现，多种细胞因子参与了子宫内膜细胞着床、增殖以及子宫内膜异位症病变形成过程中的相关事件。其中一种细胞因子——血管内皮生长因子（VEGF），似乎在异位子宫内膜病变的新生血管形成和着床过程中发挥着非常重要的作用。在本研究中，我们评估了子宫内膜异位症患者血清中VEGF的浓度，并发现美国生育学会（AFS）评分与腹膜子宫内膜异位症中VEGF浓度呈负相关。上述结果并未证实之前有关VEGF在子宫内膜异位症发病机制中作用的观察结果。
