Wołczyński S, Swiatecka J, Anchim T, Dabrowska M, Dziecioł J
Zakładu Endokrynologii Ginekologicznej AM w Białymstoku.
Ginekol Pol. 2000 Sep;71(9):1147-52.
Cancer growth follows fine balance disturbance between cell proliferation, differentiation and death. It has been shown that mutation of 4 to 5 genes controlling cellular proliferation events may be contributive to carcinogenesis. Estrogens play a central role in reproductive physiology. They are also a causative factors in the pathogenesis of neoplastic and non-neoplastic diseases, including breast cancer. The estrogen dependency of human breast cancer has been successfully exploited in the treatment of early and advanced diseases and provides a unique opportunity for chemoprevention of this common malignancy. The aim of present study was to examine the effects of tamoxifen and raloxifen on the induction of apoptosis and proliferative activity of human breast adenocarcinoma MCF-7 cells. It has been found that both tamoxifen and raloxifen decreased the speed of cell cycle in MCF-7 cells and acts as proapoptotic factors. It reduces viability of cancer cells and probability of neoplastic clone multiplification. This effect conducts to limitation of cancer expansion.
癌症的生长遵循细胞增殖、分化和死亡之间精细平衡的紊乱。已有研究表明，控制细胞增殖事件的4至5个基因发生突变可能有助于致癌作用。雌激素在生殖生理学中起着核心作用。它们也是包括乳腺癌在内的肿瘤性和非肿瘤性疾病发病机制中的致病因素。人类乳腺癌的雌激素依赖性已成功应用于早期和晚期疾病的治疗，并为这种常见恶性肿瘤的化学预防提供了独特的机会。本研究的目的是检测他莫昔芬和雷洛昔芬对人乳腺腺癌MCF-7细胞凋亡诱导和增殖活性的影响。已发现他莫昔芬和雷洛昔芬均降低了MCF-7细胞的细胞周期速度，并作为促凋亡因子发挥作用。它降低了癌细胞的活力和肿瘤克隆增殖的可能性。这种作用导致癌症扩展受到限制。
