Dario A, Cerati M, Taborelli M, Finzi G, Pozzi M, Dorizzi A
Neurosurgical Department, Varese Regional Hospital and Macchi Foundation, Italy.
J Neurooncol. 2000 Jun;48(2):131-4. doi: 10.1023/a:1006400418607.
The authors report a case of pineocytoma in a 44-year-old woman suffering from headache, vomiting and Parinaud syndrome. At histopathological examination the neoplasm showed a ill-defined lobulate pattern with some small pineocytomatous rosettes. The electron-microscopy revealed cells of moderate size and oval nuclei with smooth nuclear envelopes; well-developed organelles were found in the, abundant cytoplasm. The chromosome analysis revealed this kariotype: 58-59, XXX, -4, -5, -13, - 14, -15, + 19. This is the first report of a pineocytoma with ultrastructural and cytogenetic study; it confirms the literature findings of the electron-microscopy, whereas there is partial accordance with the previous cytogenetic studies.
作者报告了一例44岁患有头痛、呕吐和帕里诺德综合征的女性松果体细胞瘤病例。组织病理学检查显示肿瘤呈边界不清的分叶状，伴有一些小的松果体细胞瘤性菊形团。电子显微镜检查发现细胞大小适中，核呈椭圆形，核膜光滑；丰富的细胞质中可见发育良好的细胞器。染色体分析显示核型为：58 - 59，XXX，-4，-5，-13，-14，-15，+19。这是首例伴有超微结构和细胞遗传学研究的松果体细胞瘤报告；它证实了电子显微镜检查的文献发现，而在细胞遗传学方面与先前的研究部分相符。
