Malaspina D, Bruder G, Furman V, Gorman J M, Berman A, Van Heertum R
Department of Psychiatry, Columbia University, New York, USA.
J Neuropsychiatry Clin Neurosci. 2000 Fall;12(4):485-92. doi: 10.1176/jnp.12.4.485.
Schizophrenia patients vary in right ear advantage (REA) on dichotic listening tests for assessing left hemispheric dominance for language processing. The authors examined if patients with low REA differed from other patients in symptoms and in resting brain metabolism. SPECT was conducted during visual fixation for 9 healthy control subjects and 16 schizophrenia patients: 8 with normal and 8 with diminished REA. REA-diminished patients had greater positive symptoms and lower mental status scores (all P<0.05) and had right middle temporal gyrus hypermetabolism. Both schizophrenia groups had decreased right frontal and increased medial temporal lobe metabolism vs. control subjects. REA-diminished patients had right temporal lobe hypermetabolism under a resting condition (eyes open, visual fixation). Results suggest reduced right ear (left hemisphere) advantage for dichotic word perception in schizophrenia is related to a predisposition to overactivate right temporal lobe regions and to positive symptoms. In contrast, the prefrontal-medial temporal imbalance present in both patient groups may typify the schizophrenia syndrome.
精神分裂症患者在用于评估语言处理左半球优势的双耳分听测试中的右耳优势（REA）存在差异。作者研究了REA较低的患者在症状和静息脑代谢方面是否与其他患者不同。对9名健康对照者和16名精神分裂症患者在视觉注视期间进行了单光子发射计算机断层扫描（SPECT）：8名REA正常，8名REA减弱。REA减弱的患者有更明显的阳性症状和更低的精神状态评分（均P<0.05），并且右颞中回代谢亢进。与对照者相比，两个精神分裂症组的右额叶代谢均降低，内侧颞叶代谢均增加。REA减弱的患者在静息状态（睁眼、视觉注视）下右颞叶代谢亢进。结果表明，精神分裂症患者在双耳分听单词感知中右耳（左半球）优势降低与右颞叶区域过度激活的易感性以及阳性症状有关。相比之下，两个患者组中存在的前额叶-内侧颞叶失衡可能是精神分裂症综合征的典型特征。
