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本文引用的文献

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Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure.充血性心力衰竭患者输注肾上腺髓质素的血流动力学、肾脏及激素效应
Circulation. 2000 Feb 8;101(5):498-503. doi: 10.1161/01.cir.101.5.498.
2
Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension.口服活性前列环素类似物对原发性肺动脉高压门诊患者生存率的影响。
J Am Coll Cardiol. 1999 Oct;34(4):1188-92. doi: 10.1016/s0735-1097(99)00312-5.
3
A simple immunoradiometric assay for measuring the entire molecules of adrenomedullin in human plasma.一种用于测量人血浆中肾上腺髓质素完整分子的简单免疫放射分析方法。
Clin Chim Acta. 1999 Sep;287(1-2):131-43. doi: 10.1016/s0009-8981(99)00128-x.
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Mechanisms of adrenomedullin-induced increase of pulmonary blood flow in fetal sheep.肾上腺髓质素诱导胎羊肺血流量增加的机制。
Pediatr Res. 1999 Feb;45(2):276-81. doi: 10.1203/00006450-199902000-00020.
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Increased plasma levels of adrenomedullin in patients with pulmonary hypertension.肺动脉高压患者血浆肾上腺髓质素水平升高。
Clin Sci (Lond). 1999 Jan;96(1):33-9.
6
Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline.对用野百合碱处理的大鼠持续输注肾上腺髓质素可降低肺动脉高压并减轻右心室肥厚。
Eur J Pharmacol. 1998 Aug 14;355(1):33-9. doi: 10.1016/s0014-2999(98)00475-0.
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Effect of adrenomedullin on cAMP and cGMP levels in rat cardiac myocytes and nonmyocytes.
Eur J Pharmacol. 1998 Jul 24;353(2-3):337-44. doi: 10.1016/s0014-2999(98)00400-2.
8
Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide.介导新型正性肌力肽肾上腺髓质素作用的非cAMP依赖机制的证据。
Circulation. 1998 Mar 24;97(11):1062-70. doi: 10.1161/01.cir.97.11.1062.
9
Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension.原发性肺动脉高压患者长期使用依前列醇（前列环素）治疗可降低肺血管阻力。
N Engl J Med. 1998 Jan 29;338(5):273-7. doi: 10.1056/NEJM199801293380501.
10
Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension.在肺动脉高压中，血浆脑钠肽水平与右心室功能障碍的程度成正比增加。
J Am Coll Cardiol. 1998 Jan;31(1):202-8. doi: 10.1016/s0735-1097(97)00452-x.

肾上腺髓质素对肺动脉高压患者的血流动力学和激素影响

Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension.

作者信息

Nagaya N, Nishikimi T, Uematsu M, Satoh T, Oya H, Kyotani S, Sakamaki F, Ueno K, Nakanishi N, Miyatake K, Kangawa K

机构信息

Division of Cardiology, Department of Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan.

出版信息

Heart. 2000 Dec;84(6):653-8. doi: 10.1136/heart.84.6.653.

DOI:10.1136/heart.84.6.653
PMID:11083748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1729511/
Abstract

OBJECTIVE

To investigate whether infusion of adrenomedullin, a potent vasorelaxant peptide, has beneficial haemodynamic and hormonal effects in patients with pulmonary hypertension.

PATIENTS AND DESIGN

The haemodynamic and hormonal responses to intravenous infusion of adrenomedullin (0.05 microgram/kg/min) or placebo were examined in 13 patients with precapillary pulmonary hypertension.

RESULTS

Infusion of adrenomedullin produced a 44% increase in cardiac index (mean (SD) 1.8 (0.2) to 2.6 (0.3) l/min/m(2), p < 0. 05) and a 32% decrease in pulmonary vascular resistance (19.7 (1.4) to 13.4 (1.3) units, p < 0.05), with a 4% reduction in mean pulmonary arterial pressure (62 (4) to 59 (4) mm Hg, NS). Adrenomedullin also decreased mean systemic arterial pressure (81 (3) to 72 (4) mm Hg, p < 0.05) and increased heart rate (73 (4) to 79 (4) beats/min, p < 0.05). Adrenomedullin decreased plasma aldosterone (9.8 (2.5) to 7.1 (1.5) ng/dl, p < 0.05) without significant changes in plasma renin activity. Plasma atrial and brain natriuretic peptides tended to decrease with adrenomedullin, although these changes did not reach significance. The haemodynamic and hormonal variables remained unchanged during placebo infusion.

CONCLUSIONS

Intravenous adrenomedullin has beneficial haemodynamic and hormonal effects in patients with precapillary pulmonary hypertension.

摘要

目的

研究给予强效血管舒张肽肾上腺髓质素对肺动脉高压患者是否具有有益的血流动力学和激素效应。

患者与设计

对13例毛细血管前肺动脉高压患者静脉输注肾上腺髓质素（0.05微克/千克/分钟）或安慰剂后，检测其血流动力学和激素反应。

结果

输注肾上腺髓质素使心脏指数增加44%（均值（标准差）从1.8（0.2）升/分钟/平方米增至2.6（0.3）升/分钟/平方米，p<0.05），肺血管阻力降低32%（从19.7（1.4）单位降至13.4（1.3）单位，p<0.05），平均肺动脉压降低4%（从62（4）毫米汞柱降至59（4）毫米汞柱，无统计学意义）。肾上腺髓质素还使平均体动脉压降低（从81（3）毫米汞柱降至72（4）毫米汞柱，p<0.05），心率增加（从73（4）次/分钟增至79（4）次/分钟，p<0.05）。肾上腺髓质素使血浆醛固酮降低（从9.8（2.5）纳克/分升降至7.1（1.5）纳克/分升，p<0.05），而血浆肾素活性无显著变化。输注肾上腺髓质素后，血浆心钠肽和脑钠肽有降低趋势，尽管这些变化无统计学意义。输注安慰剂期间，血流动力学和激素变量无变化。

结论

静脉输注肾上腺髓质素对毛细血管前肺动脉高压患者具有有益的血流动力学和激素效应。