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Mechanism of adrenomedullin 2/intermedin mediated vasorelaxation in rat main pulmonary artery.肾上腺髓质素 2/中介素介导大鼠肺动脉血管舒张的机制。
Peptides. 2018 May;103:65-71. doi: 10.1016/j.peptides.2018.03.015. Epub 2018 Mar 26.
2
Effect of intermedin/adrenomedullin on the pulmonary vascular bed in hypoxia-induced pulmonary hypertensive rats.中介素/肾上腺髓质素对低氧诱导的肺动脉高压大鼠肺血管床的影响。
Life Sci. 2018 Jan 1;192:62-67. doi: 10.1016/j.lfs.2017.11.031. Epub 2017 Nov 21.
3
Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases.肾上腺髓质素 2/中介素：一种潜在的治疗心脏代谢疾病的药物候选物。
Br J Pharmacol. 2018 Apr;175(8):1230-1240. doi: 10.1111/bph.13814. Epub 2017 May 16.
4
Calcitonin gene-related peptide: physiology and pathophysiology.降钙素基因相关肽：生理学与病理生理学
Physiol Rev. 2014 Oct;94(4):1099-142. doi: 10.1152/physrev.00034.2013.
5
Intermedin/adrenomedullin2: an autocrine/paracrine factor in vascular homeostasis and disease.中间介质/肾上腺髓质素2：血管稳态与疾病中的一种自分泌/旁分泌因子。
Sci China Life Sci. 2014 Aug;57(8):781-9. doi: 10.1007/s11427-014-4701-7. Epub 2014 Aug 8.
6
Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats.中介素通过受体介导的 cAMP/PKA 信号通路增强大鼠孤束核中的交感神经输出。
Peptides. 2013 Sep;47:1-6. doi: 10.1016/j.peptides.2013.05.002. Epub 2013 Jun 29.
7
Intermedin modulates hypoxic pulmonary vascular remodeling by inhibiting pulmonary artery smooth muscle cell proliferation.中介素通过抑制肺动脉平滑肌细胞增殖来调节低氧性肺血管重构。
Pulm Pharmacol Ther. 2014 Feb;27(1):1-9. doi: 10.1016/j.pupt.2013.06.004. Epub 2013 Jun 22.
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Intermedin suppresses pressure overload cardiac hypertrophy through activation of autophagy.中介素通过激活自噬抑制压力超负荷性心肌肥厚。
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9
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[Effect of hypoxia on the expressions of intermedin/ adrenomedullin2 in plasma and the tissues of heart and lung in rats].[缺氧对大鼠血浆及心肺组织中中介素/肾上腺髓质素2表达的影响]
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基因相关肽家族的心肺效应

The Cardiopulmonary Effects of the Gene-related Peptide Family.

作者信息

Tellİ Gökçen, Tel Banu Cahide, GÜmÜŞel Bülent

机构信息

Hacettepe University Faculty of Pharmacy, Department of Pharmacology, Ankara, Turkey.

Lokman Hekim University Faculty of Pharmacy, Department of Pharmacology, Ankara, Turkey.

出版信息

Turk J Pharm Sci. 2020 Jun;17(3):349-356. doi: 10.4274/tjps.galenos.2019.47123. Epub 2020 Jun 22.

DOI:10.4274/tjps.galenos.2019.47123
PMID:32636714
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7336034/
Abstract

Cardiopulmonary diseases are very common among the population. They are high-cost diseases and there are still no definitive treatments. The roles of members of the calcitonin-gene related-peptide (CGRP) family in treating cardiopulmonary diseases have been studied for many years and promising results obtained. Especially in recent years, two important members of the family, adrenomedullin and adrenomedullin2/intermedin, have been considered new treatment targets in cardiopulmonary diseases. In this review, the roles of CGRP family members in cardiopulmonary diseases are investigated based on the studies performed to date.

摘要

心肺疾病在人群中非常常见。它们是高成本疾病，目前仍没有确切的治疗方法。降钙素基因相关肽（CGRP）家族成员在治疗心肺疾病中的作用已经研究多年，并取得了有前景的结果。特别是近年来，该家族的两个重要成员，肾上腺髓质素和肾上腺髓质素2/中间介素，已被视为心肺疾病的新治疗靶点。在这篇综述中，我们根据迄今为止进行的研究，探讨了CGRP家族成员在心肺疾病中的作用。