基因相关肽家族的心肺效应
The Cardiopulmonary Effects of the Gene-related Peptide Family.
作者信息
Tellİ Gökçen, Tel Banu Cahide, GÜmÜŞel Bülent
机构信息
Hacettepe University Faculty of Pharmacy, Department of Pharmacology, Ankara, Turkey.
Lokman Hekim University Faculty of Pharmacy, Department of Pharmacology, Ankara, Turkey.
出版信息
Turk J Pharm Sci. 2020 Jun;17(3):349-356. doi: 10.4274/tjps.galenos.2019.47123. Epub 2020 Jun 22.
Abstract
Cardiopulmonary diseases are very common among the population. They are high-cost diseases and there are still no definitive treatments. The roles of members of the calcitonin-gene related-peptide (CGRP) family in treating cardiopulmonary diseases have been studied for many years and promising results obtained. Especially in recent years, two important members of the family, adrenomedullin and adrenomedullin2/intermedin, have been considered new treatment targets in cardiopulmonary diseases. In this review, the roles of CGRP family members in cardiopulmonary diseases are investigated based on the studies performed to date.
摘要
心肺疾病在人群中非常常见。它们是高成本疾病，目前仍没有确切的治疗方法。降钙素基因相关肽（CGRP）家族成员在治疗心肺疾病中的作用已经研究多年，并取得了有前景的结果。特别是近年来，该家族的两个重要成员，肾上腺髓质素和肾上腺髓质素2/中间介素，已被视为心肺疾病的新治疗靶点。在这篇综述中，我们根据迄今为止进行的研究，探讨了CGRP家族成员在心肺疾病中的作用。
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2
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Life Sci. 2018 Jan 1;192:62-67. doi: 10.1016/j.lfs.2017.11.031. Epub 2017 Nov 21.
3
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4
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