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1
Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study.风湿热和猩红热患者血清与A组链球菌M蛋白、心肌肌球蛋白及心肌肌钙蛋白的反应性：一项回顾性研究
Infect Immun. 2000 Dec;68(12):7132-6. doi: 10.1128/IAI.68.12.7132-7136.2000.
2
Immunological relationship between the class I epitope of streptococcal M protein and myosin.链球菌M蛋白I类表位与肌球蛋白之间的免疫关系。
Infect Immun. 1998 Sep;66(9):4418-24. doi: 10.1128/IAI.66.9.4418-4424.1998.
3
Identification of cardiac autoantigens in human heart cDNA libraries using acute rheumatic fever sera.利用急性风湿热血清在人心脏cDNA文库中鉴定心脏自身抗原。
J Autoimmun. 1994 Apr;7(2):243-61. doi: 10.1006/jaut.1994.1019.
4
Epitopes of streptococcal M proteins shared with cardiac myosin.与心肌肌球蛋白共有的链球菌M蛋白表位。
J Exp Med. 1985 Aug 1;162(2):583-91. doi: 10.1084/jem.162.2.583.
5
Elevated levels of IgG specific antimyosin antibodies in acute rheumatic fever (ARF): differential profiles of antibodies to myosin and soluble myocardial antigens in ARF, acute glomerulonephritis and group A streptococcal pharyngitis.急性风湿热（ARF）中抗肌球蛋白特异性IgG抗体水平升高：ARF、急性肾小球肾炎和A组链球菌性咽炎中抗肌球蛋白抗体及可溶性心肌抗原的差异特征
J Clin Lab Immunol. 1993;40(4):149-61.
6
Antibody levels to the class I and II epitopes of the M protein and myosin are related to group A streptococcal exposure in endemic populations.针对M蛋白和肌球蛋白I类和II类表位的抗体水平与流行地区人群中A组链球菌暴露情况相关。
Int Immunol. 2001 Oct;13(10):1335-43. doi: 10.1093/intimm/13.10.1335.
7
Immunological crossreactivity between the class I epitope of streptococcal M protein and myosin.链球菌M蛋白的I类表位与肌球蛋白之间的免疫交叉反应性。
Adv Exp Med Biol. 1997;418:887-92. doi: 10.1007/978-1-4899-1825-3_208.
8
Cloning and sequence analysis of a gene encoding a 67-kilodalton myosin-cross-reactive antigen of Streptococcus pyogenes reveals its similarity with class II major histocompatibility antigens.化脓性链球菌编码一种67千道尔顿肌球蛋白交叉反应抗原的基因的克隆及序列分析显示其与II类主要组织相容性抗原有相似性。
Infect Immun. 1994 Jun;62(6):2440-9. doi: 10.1128/iai.62.6.2440-2449.1994.
9
Antibodies in the sera of acute rheumatic fever patients bind to human cardiac tropomyosin.急性风湿热患者血清中的抗体与人类心脏肌钙蛋白结合。
J Autoimmun. 1997 Feb;10(1):99-106. doi: 10.1006/jaut.1996.0107.
10
A longitudinal study of antibody responses to selected host antigens in rheumatic fever and rheumatic heart disease.风湿热和风湿性心脏病患者对特定宿主抗原抗体反应的纵向研究。
J Med Microbiol. 2021 May;70(5). doi: 10.1099/jmm.0.001355.

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1
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Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae.分子模拟、自身免疫和感染：A 组链球菌的交叉反应抗原及其后果。
Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.GPP3-0045-2018.
4
Repeat exposure to group A streptococcal M protein exacerbates cardiac damage in a rat model of rheumatic heart disease.反复暴露于A组链球菌M蛋白会加重风湿性心脏病大鼠模型的心脏损伤。
Autoimmunity. 2016 Dec;49(8):563-570. doi: 10.1080/08916934.2016.1217999. Epub 2016 Aug 25.

本文引用的文献

1
QUANTITATIVE ANTISTREPTOKINASE STUDIES IN PATIENTS INFECTED WITH GROUP A HEMOLYTIC STREPTOCOCCI: A COMPARISON WITH SERUM ANTISTREPTOLYSIN AND GAMMA GLOBULIN LEVELS WITH SPECIAL REFERENCE TO THE OCCURRENCE OF RHEUMATIC FEVER.A组溶血性链球菌感染患者的抗链激酶定量研究：与血清抗链球菌溶血素及γ球蛋白水平的比较，特别提及风湿热的发生情况
J Clin Invest. 1948 Jul;27(4):425-34. doi: 10.1172/JCI101986.
2
Current knowledge of type-specific M antigens of group A streptococci.A组链球菌特定类型M抗原的现有知识。
J Immunol. 1962 Sep;89:307-13.
3
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. III. PRESENCE IN HUMAN SERA OF STREPTOCOCCAL ANTIBODY CROSS-REACTIVE WITH HEART TISSUE. ASSOCIATION WITH STREPTOCOCCAL INFECTION, RHEUMATIC FEVER, AND GLOMERULONEPHRITIS.链球菌与组织抗原的免疫关系。III. 人血清中与心脏组织发生交叉反应的链球菌抗体的存在。与链球菌感染、风湿热和肾小球肾炎的关联。
J Exp Med. 1964 Apr 1;119(4):651-66. doi: 10.1084/jem.119.4.651.
4
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE.链球菌抗原与组织抗原的免疫学关系。I. A 组某些链球菌菌株中一种抗原的特性，该抗原与人心脏组织存在免疫交叉反应
J Immunol. 1963 Apr;90:595-606.
5
The concept of autoantibodies in rheumatic fever and in the postcommissurotomy state.风湿热和二尖瓣分离术后状态下自身抗体的概念。
Ann N Y Acad Sci. 1960 Jun 30;86:974-91. doi: 10.1111/j.1749-6632.1960.tb42854.x.
6
Immunological relationship between the class I epitope of streptococcal M protein and myosin.链球菌M蛋白I类表位与肌球蛋白之间的免疫关系。
Infect Immun. 1998 Sep;66(9):4418-24. doi: 10.1128/IAI.66.9.4418-4424.1998.
7
Molecular analysis of human cardiac myosin-cross-reactive B- and T-cell epitopes of the group A streptococcal M5 protein.A组链球菌M5蛋白的人心脏肌球蛋白交叉反应性B细胞和T细胞表位的分子分析
Infect Immun. 1997 Sep;65(9):3913-23. doi: 10.1128/iai.65.9.3913-3923.1997.
8
Antibodies in the sera of acute rheumatic fever patients bind to human cardiac tropomyosin.急性风湿热患者血清中的抗体与人类心脏肌钙蛋白结合。
J Autoimmun. 1997 Feb;10(1):99-106. doi: 10.1006/jaut.1996.0107.
9
Persistent elevation of immunoglobulin G titer against the C region of recombinant group A streptococcal M protein in patients with rheumatic fever.风湿热患者中针对重组A组链球菌M蛋白C区的免疫球蛋白G滴度持续升高。
Pediatr Res. 1996 Feb;39(2):336-42. doi: 10.1203/00006450-199602000-00024.
10
Streptococcal M protein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsakieviral myocarditis.与肌球蛋白相似的链球菌M蛋白肽在MRL/++小鼠中诱导CD4+ T细胞依赖性心肌炎，并诱导对柯萨奇病毒性心肌炎的部分耐受性。
J Immunol. 1996 May 1;156(9):3528-34.

风湿热和猩红热患者血清与A组链球菌M蛋白、心肌肌球蛋白及心肌肌钙蛋白的反应性：一项回顾性研究

Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study.

作者信息

Jones K F, Whitehead S S, Cunningham M W, Fischetti V A

机构信息

SIGA Research Laboratories, Corvallis, Oregon 97333, USA.

出版信息

Infect Immun. 2000 Dec;68(12):7132-6. doi: 10.1128/IAI.68.12.7132-7136.2000.

DOI:10.1128/IAI.68.12.7132-7136.2000
PMID:11083840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC97825/
Abstract

Archived sera (collected in 1946) from acute rheumatic fever (ARF) and untreated scarlet fever and/or pharyngitis patients were reacted with streptococcal M protein, cardiac myosin, and cardiac tropomyosin. Except for very low levels to tropomyosin, antibodies to other antigens were not elevated in the sera of ARF patients relative to those of non-ARF patients, even though there was roughly equivalent exposure to group A streptococci. This suggests that antibodies to these molecules may not play a central role in the induction of ARF.

摘要

将1946年采集的急性风湿热（ARF）患者以及未经治疗的猩红热和/或咽炎患者的存档血清，与链球菌M蛋白、心肌肌球蛋白和心肌肌钙蛋白进行反应。除了对肌钙蛋白的反应水平非常低外，与非ARF患者相比，ARF患者血清中针对其他抗原的抗体并未升高，尽管两组患者接触A组链球菌的情况大致相同。这表明针对这些分子的抗体可能在ARF的诱发过程中并不起核心作用。