Dick H B, Augustin A J
Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany.
J Cataract Refract Surg. 2000 Nov;26(11):1667-72. doi: 10.1016/s0886-3350(00)00362-x.
To evaluate the effectiveness of a perfluorocarbon-perfluorohexyloctane (PFHO)-in removing silicone oil from different intraocular lenses (IOLs) and determine whether any removal technique enhances the removal of silicone oil.
Six IOL materials were analyzed: standard poly(methyl methacrylate) (PMMA), heparin-surface-modified (HSM) PMMA, AcrySof, 2 polyHEMAs with different water contents, and a second-generation SLM-2 silicone. One or 2 microL of a highly viscous silicone oil (5700 cs) was applied to the center of each IOL optic. Perfluorohexyloctane (2 mL) was then used to remove the silicone oil by 1 of 3 techniques: immersion of the IOL in PFHO; irrigation of the silicone oil with a small, blunt cannula; mechanical wiping with a PFHO-saturated Merocel swab (used only when irrigation failed). Next, each IOL was examined by light and scanning electron microscopy. The expanse of silicone oil residue remaining on the IOLs was objectively quantified using an integrated computerized analysis system combined with energy-dispersive spectrometry.
After application of 1 microL silicone oil, immersion in PFHO did not remove silicone oil from any IOL material. Irrigation with PFHO removed the silicone oil from the HSM PMMA and polyHEMA IOLs, but oil remained on the other lens materials. Mechanical wiping was necessary to remove the oil from the PMMA, AcrySof, and silicone IOLs. Attempts to remove 2 microL of silicone oil produced similar results. Although mechanical wiping of the AcrySof IOL removed all silicone oil, a slight residue remained on the PMMA and silicone IOLs. The PFHO irrigation removed significantly more silicone oil from the HSM PMMA than the unmodified PMMA IOL (P =.001). More silicone oil was removed from polyHEMA IOLs than from the AcrySof or silicone IOLs (P =.05).
Although PFHO can remove silicone oil, it is of limited usefulness. The effectiveness of PFHO depends on the removal technique, IOL material, and amount of silicone oil present. Based on these results, we recommend PFHO irrigation followed by mechanical wiping with a PFHO-saturated swab.
评估全氟己基辛烷（PFHO）从不同人工晶状体（IOL）中去除硅油的效果，并确定是否有任何去除技术能增强硅油的去除效果。
分析了六种IOL材料：标准聚甲基丙烯酸甲酯（PMMA）、肝素表面改性（HSM）的PMMA、AcrySof、两种不同含水量的聚甲基丙烯酸羟乙酯（polyHEMA）以及第二代SLM - 2硅胶。将1或2微升高粘性硅油（5700厘沲）涂覆在每个IOL光学部的中心。然后用全氟己基辛烷（2毫升）通过以下三种技术之一去除硅油：将IOL浸入PFHO中；用小钝头套管冲洗硅油；用PFHO饱和的Merocel拭子进行机械擦拭（仅在冲洗失败时使用）。接下来，通过光学显微镜和扫描电子显微镜检查每个IOL。使用结合能谱分析的集成计算机分析系统客观地量化残留在IOL上的硅油残留范围。
涂抹1微升硅油后，将IOL浸入PFHO中未能从任何IOL材料中去除硅油。用PFHO冲洗可从HSM PMMA和polyHEMA IOL中去除硅油，但其他镜片材料上仍有硅油残留。需要进行机械擦拭才能从PMMA、AcrySof和硅胶IOL上去除硅油。尝试去除2微升硅油产生了类似的结果。虽然对AcrySof IOL进行机械擦拭可去除所有硅油，但PMMA和硅胶IOL上仍有少量残留。与未改性的PMMA IOL相比，PFHO冲洗从HSM PMMA上去除的硅油明显更多（P = 0.001）。从polyHEMA IOL上去除的硅油比从AcrySof或硅胶IOL上更多（P = 0.05）。
虽然PFHO可以去除硅油，但其用途有限。PFHO的有效性取决于去除技术IOL材料和存在的硅油量。基于这些结果，我们建议先用PFHO冲洗，然后用PFHO饱和的拭子进行机械擦拭。
