Martel J, Duclos J Y, Darrouzet V, Guyot M, Bébéar J P
Service d'ORL et de chirurgie cervico-faciale, Service de médecine nucléaire, Hôpital Pellegrin C.H.U. de Bordeaux, 33076 Bordeaux Cedex.
Ann Otolaryngol Chir Cervicofac. 2000 Nov;117(5):291.
Malignant or progressive necrotizing otitis extrema is an uncommon but severe infectious condition of the external auditory canal. Over a period of four years, we treated 22 patients: 60% had diabetes (1/4 insulin dependent) and 13% were immunodepressed. The causal germ was Pseudomonas aeruginosa in 87% of cases. The pretherapeutic work-up included a computed tomography scan and a technetium scintigraphy to confirm diagnosis and assess extension. Repeated scintigraphies with gallium were used to follow the course under treatment. Medical treatment was used in most cases (16/22) with parenteral antibiotic therapy using a third-generation cephalosporin (ceftazidime or ceftriaxone) and a fluoroquinolone (ciprofloxacin or ofloxacin) and, if there was no contraindication, hyperbaric oxygen. Surgery is not indicated in malignant otitis externa. We had a 95% cure rate with only 10% recurrence. We reviewed the data in the literature on malignant otitis externa and present the important diagnostic, imaging and therapeutic aspects.
恶性或进行性坏死性外耳道炎是一种外耳道罕见但严重的感染性疾病。在四年时间里,我们治疗了22例患者:60%患有糖尿病(四分之一为胰岛素依赖型),13%存在免疫抑制。87%的病例中致病病菌为铜绿假单胞菌。治疗前的检查包括计算机断层扫描和锝闪烁扫描,以确诊并评估病变范围。使用镓进行重复闪烁扫描以监测治疗过程。大多数病例(16/22)采用药物治疗——使用第三代头孢菌素(头孢他啶或头孢曲松)和氟喹诺酮类药物(环丙沙星或氧氟沙星)进行胃肠外抗生素治疗,并且在无禁忌证的情况下采用高压氧治疗。恶性外耳道炎不适合手术治疗。我们的治愈率为95%,复发率仅为10%。我们回顾了文献中关于恶性外耳道炎的数据,并介绍了重要的诊断、影像学和治疗方面的情况。