Tisch M, Lorenz K J, Harm M, Lampl L, Maier H
Oberstabsarzt, Bundeswehrkrankenhaus Ulm, Abteilung für Hals-Nasen-Ohren-Heilkunde, Kopf-Hals-Chirurgie.
HNO. 2003 Apr;51(4):315-20. doi: 10.1007/s00106-002-0713-x.
Even today, necrotizing otitis externa is still a life-threatening condition. The standard treatment concepts based on antibiotic therapy, topical treatment and--if necessary--surgical debridement of necrotic tissue, remain ineffective in many cases. In advanced stages, necrotizing otitis externa can therefore be expected to result in severe functional impairment or even a fatal outcome.
We describe our experience with a multimodal treatment concept that we have been using with great success at the Federal Armed Forces Hospital in Ulm since 1987. This treatment is based on four pillars: 1. Surgical debridement, 2. Use of a combination of antibiotics, and 3. Administration of specific immunoglobulins, accompanied by, 4. Hyperbaric oxygen therapy
Over a period of more than 5 years 16 of the 22 patients treated on the basis of this multimodal concept remained free of recurrences. In addition, significant reductions in analgesic use and in the insulin doses needed by diabetic patients were possible.
The treatment concept under scrutiny has proved particularly successful. The various modes involved and the results of this combined therapy are discussed.
即便在当今,坏死性外耳道炎仍是一种危及生命的疾病。基于抗生素治疗、局部治疗以及必要时对坏死组织进行手术清创的标准治疗理念,在许多情况下仍不见效。因此,在疾病晚期,坏死性外耳道炎可能会导致严重的功能障碍甚至致命后果。
我们描述了自1987年以来一直在乌尔姆联邦武装部队医院成功应用的多模式治疗理念的经验。该治疗基于四个支柱:1. 手术清创;2. 使用抗生素组合;3. 给予特异性免疫球蛋白,同时辅以4. 高压氧治疗。
在超过5年的时间里,基于这种多模式理念接受治疗的22名患者中有16名未复发。此外,还能显著减少镇痛药物的使用以及糖尿病患者所需的胰岛素剂量。
所审查的治疗理念已证明特别成功。文中讨论了这种联合治疗所涉及的各种方式及其结果。