Takigawa M, Wang H, Hamada K, Shiratani T, Takenouchi K
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
Ann N Y Acad Sci. 2000 Sep;914:311-5. doi: 10.1111/j.1749-6632.2000.tb05206.x.
Methamphetamine (MAP) can reinforce intracranial self-stimulation (ICSS) in rats, that is, reward-seeking behavior. However, the ICSS can be inhibited by the stereotyped behavior induced by MAP. This study was designed to observe the mutual information flow between prefrontal cortex (PFC) and ventral tegmental area (VTA) using directed coherence (DC) analysis during the hyperactivity and stereotyped behavior induced by administration of MAP (a derivative of amphetamine). The DC from PFC to VTA increased at 5-7 Hz in the hyperactivity as compared to the stereotypy. In contrast, enhanced information flow from VTA to PFC was observed in the stereotypy as compared to the hyperactivity. We found a reciprocal information flow between PFC and VTA corresponding to the hyperactivity and stereotyped behavior that was induced by administration of MAP.
甲基苯丙胺（MAP）可增强大鼠的颅内自我刺激（ICSS），即奖赏寻求行为。然而，ICSS会受到MAP诱导的刻板行为的抑制。本研究旨在通过定向相干（DC）分析，观察在给予MAP（一种苯丙胺衍生物）诱导的多动和刻板行为期间，前额叶皮质（PFC）和腹侧被盖区（VTA）之间的互信息流。与刻板行为相比，在多动状态下，从PFC到VTA的DC在5-7Hz时增加。相反，与多动相比，在刻板行为中观察到从VTA到PFC的信息流增强。我们发现，PFC和VTA之间存在与给予MAP诱导的多动和刻板行为相对应的互信息流。
