Li Y, Wolf M E
Department of Neuroscience, Finch University of Health Sciences/The Chicago Medical School, IL 60064-3095, USA.
Behav Brain Res. 1997 Mar;84(1-2):285-9. doi: 10.1016/s0166-4328(96)00158-1.
We have shown previously that ibotenic acid lesions of the prefrontal cortex, performed prior to repeated amphetamine administration, do not affect sensitization of stereotyped behaviors but do prevent sensitization of post-stereotypy locomotor hyperactivity [Wolf et al., Neuroscience, 69 (1995) 417-439]. This could reflect an effect of the lesion on either development or expression of locomotor sensitization. To test the latter possibility, rats were treated with repeated amphetamine injections and tested to establish behavioral sensitization. Then, half received ibotenic acid lesions of prefrontal cortex and half received sham lesions. A second amphetamine challenge, 7 days later, demonstrated that the lesion failed to prevent expression of sensitization. Together with previous results, this suggests that intrinsic neurons of prefrontal cortex, most likely those sending excitatory amino acid-containing projections to the ventral tegmental area, are required for the development but not the expression of behavioral sensitization to amphetamine.
我们之前已经表明，在反复给予苯丙胺之前进行的前额叶皮质鹅膏蕈氨酸损伤，并不影响刻板行为的敏化，但确实能阻止刻板行为后运动性多动的敏化[Wolf等人，《神经科学》，69(1995)417 - 439]。这可能反映了损伤对运动敏化的发育或表达的影响。为了测试后一种可能性，对大鼠进行反复的苯丙胺注射并进行测试以建立行为敏化。然后，一半大鼠接受前额叶皮质的鹅膏蕈氨酸损伤，另一半接受假损伤。7天后的第二次苯丙胺激发试验表明，损伤未能阻止敏化的表达。结合之前的结果，这表明前额叶皮质的内在神经元，很可能是那些向腹侧被盖区发送含兴奋性氨基酸投射的神经元，是苯丙胺行为敏化发育所必需的，但不是其表达所必需的。
