Hattori A, Fukushima T, Yoshimura H, Abe K, Imai K
Department of Bio-Analytical Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Biol Pharm Bull. 2000 Nov;23(11):1395-7. doi: 10.1248/bpb.23.1395.
An oral administration of gamma-tocotrienol (gamma-T3) or gamma-tocopherol (gamma-Toc) to male rats caused an increase of the concentration of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman (LLU-alpha, gamma-CEHC), a natriuretic compound, in plasma with a T(max) of 9 h. The configuration at C-2 of LLU-alpha produced from gamma-T3 or gamma-Toc was assigned as S-form by an HPLC equipped with a chiral column. These data indicated that LLU-alpha was produced not only from gamma-Toc but also gamma-T3, without racemization at C-2 in rats.
给雄性大鼠口服γ-生育三烯酚（γ-T3）或γ-生育酚（γ-Toc）后，血浆中利钠化合物2,7,8-三甲基-2-（β-羧乙基）-6-羟基苯并二氢吡喃（LLU-α，γ-CEHC）的浓度会升高，达峰时间（Tmax）为9小时。通过配备手性柱的高效液相色谱法确定，由γ-T3或γ-Toc产生的LLU-α在C-2位的构型为S型。这些数据表明，LLU-α不仅可由γ-Toc产生，也可由γ-T3产生，且在大鼠体内C-2位不会发生消旋。
