Girodon F, Carli P M, Favre B, Mannone L, Houssaye S, Mugneret F, Casasnovas O, Maynadié M
Hematology Laboratory, C.H.U. de Dijon, France.
Leuk Res. 2000 Nov;24(11):979-82. doi: 10.1016/s0145-2126(00)00068-0.
We report here the case of a woman with acute myeloid leukemia with some blast cells exhibiting acute promyelocytic leukemia (APL)-like hypergranular cytoplasm. The cytologic and cytochemical aspects as well as the mature myeloid phenotype and hemostasis disorders were consistent with the diagnosis of APL. However, no t(15;17), or RARalpha gene, MLL gene or PML gene rearrangement was observed, or any other cytogenetic clonal abnormality. Coexpression on blast cells of CD33 and CD56 without CD34, CD16 or HLA-DR, suggested a myeloid/natural killer cell acute leukemia.
