用于诊断克雅氏病的14-3-3检测结果存在误导性。
Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease.
作者信息
Chapman T, McKeel D W, Morris J C
机构信息
Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Neurology. 2000 Nov 14;55(9):1396-7. doi: 10.1212/wnl.55.9.1396.
PMID:11087791
Abstract
The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
摘要
克雅氏病（CJD）的确诊需要对脑组织进行分析。脑脊液中14-3-3蛋白检测呈阳性，被认为对克雅氏病患者具有高度敏感性和特异性。作者描述了3例脑脊液14-3-3检测出现假阳性或假阴性的患者。在克雅氏病的诊断中，建议谨慎对待对这种假定生物标志物的过度依赖。
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