Haïk S, Brandel J P, Sazdovitch V, Delasnerie-Lauprêtre N, Peoc'h K, Laplanche J L, Privat N, Duyckaerts C, Kemeny J L, Kopp N, Laquerrière A, Mohr M, Deslys J P, Dormont D, Hauw J J
Raymond Escourolle Neuropathology Laboratory, Pitié-Salpêtrière Hospital, Paris, France.
Neurology. 2000 Nov 14;55(9):1401-4. doi: 10.1212/wnl.55.9.1401.
Discriminating Creutzfeldt-Jakob disease (CJD) from dementia with Lewy bodies (DLB) may be clinically difficult to achieve. The authors describe 10 patients with DLB initially referred to the French Network of Human Spongiform Encephalopathies as having suspected CJD. In a series of 465 autopsied cases, DLB ranked second among degenerative alternative diagnoses to CJD. The authors analyzed the factors that contributed to misleading the diagnosis, and suggest that the detection of 14-3-3 protein in CSF may be useful to distinguish CJD from DLB.
临床上很难将克雅氏病（CJD）与路易体痴呆（DLB）区分开来。作者描述了10例最初被转诊至法国人类海绵状脑病网络的疑似CJD的DLB患者。在一系列465例尸检病例中，DLB在CJD的退行性替代诊断中排名第二。作者分析了导致诊断失误的因素，并提出检测脑脊液中的14-3-3蛋白可能有助于区分CJD和DLB。
