Albin R L, Koeppe R A, Chervin R D, Consens F B, Wernette K, Frey K A, Aldrich M S
Department of Neurology, University of Michigan, Ann Arbor, USA.
Neurology. 2000 Nov 14;55(9):1410-2. doi: 10.1212/wnl.55.9.1410.
REM sleep behavior disorder (RBD) is a possible herald of neurodegenerative disorders with parkinsonism. The authors determined the density of striatal dopaminergic terminals with [11C]dihydrotetrabenazine PET in six elderly subjects with chronic idiopathic RBD and 19 age-appropriate controls. In subjects with RBD, there were significant reductions in striatal [11C]dihydrotetrabenazine binding, particularly in the posterior putamen.
