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颅内耳源性并发症:尽管治疗取得进展,但仍是一个严重问题。

[Intracranial otogenic complications: inspite of therapeutic progress still a serious problem].

作者信息

Kaftan H, Draf W

机构信息

Universitätsklinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Dresden.

出版信息

Laryngorhinootologie. 2000 Oct;79(10):609-15. doi: 10.1055/s-2000-7682.

Abstract

BACKGROUND

High-imaging modalities, antibiotics and improved microsurgical procedures have decreased morbidity and mortality of intracranial otogenic complications in the western hemisphere nowadays. However, they do occur and the resulting mortality is still about 10%.

PATIENTS AND RESULTS

We report our experiences with 22 patients, who were treated for intracranial otogenic complications (15 x meningitis, 5 x brain abscess, 1 x subdural empyema, 1 x Gradenigo's syndrome) due to cerebrospinal fluid leak in 2 patients, chronic otitis in 9 patients (5 with cholesteatoma), acute otitis media in 11 patients, between 1981 and September 1999. Five patients with acute otitis media have had predisposing anatomic pathology: 1 x inner ear malformation, 1 x status after duraplasty, 2 x dura-brain-prolapse due to temporal bone fractures and 1 x dura-brain-prolapse after antrotomy. Streptococcus pneumoniae was a common cause of intracranial-complicating acute otitis media (64%). Residual neurologic impairment was noted in 3 patients at the time of discharge. 3 patients (13.6%) died due to the otogenic intracranial complication.

CONCLUSION

Otogenic intracranial complications are potentially life threatening conditions. Early diagnosis is essential to allow appropriate antimicrobial and surgical treatment. The necessity of close cooperation between otorhinolaryngologist, pediatrician, neurologist, radiologist and neurosurgeon is stressed.

摘要

背景

如今,在西半球,高分辨率成像技术、抗生素以及改良的显微外科手术已降低了颅内耳源性并发症的发病率和死亡率。然而,这些并发症仍会发生,其导致的死亡率仍约为10%。

患者与结果

我们报告了1981年至1999年9月期间22例颅内耳源性并发症患者的治疗经验。这些患者中,15例为脑膜炎,5例为脑脓肿,1例为硬膜下积脓,1例为Gradenigo综合征;2例因脑脊液漏发病,9例因慢性中耳炎(5例伴有胆脂瘤)发病,11例因急性中耳炎发病。5例急性中耳炎患者存在解剖学易患因素:1例内耳畸形,1例硬脑膜成形术后状态,2例因颞骨骨折导致硬脑膜-脑组织脱垂,1例鼓窦切开术后硬脑膜-脑组织脱垂。肺炎链球菌是颅内并发急性中耳炎的常见病因(64%)。出院时3例患者存在残留神经功能障碍。3例患者(13.6%)死于耳源性颅内并发症。

结论

耳源性颅内并发症可能危及生命。早期诊断对于进行适当的抗菌和手术治疗至关重要。强调了耳鼻喉科医生、儿科医生、神经科医生、放射科医生和神经外科医生密切合作的必要性。

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