Rezvani M, Uzlenkova N, Whitehouse E, Frenkel L, Wilkinson J H, Ross G, Morris G M, Hopewell J W, Pilipenko N
Research Institute, University of Oxford, Churchill Hospital, UK.
Br J Radiol. 2000 Jul;73(871):771-5. doi: 10.1259/bjr.73.871.11089470.
Pig skin was used as a model to study the effectiveness of two topically applied creams, Lipochromin and Levosinum, in modifying the development of both early and late radiation damage to pig skin. Irradiated skin sites that received daily topical application of Levosinum or Lipochromin after exposure were compared with sites on the contralateral flank of the same animal that received irradiation only. Irradiation was with graded doses of 90Sr/90Y beta-rays. Incidence of moist desquamation (acute) and ischaemic dermal necrosis (late) were used as end-points. The latency period for the development of moist desquamation and its healing time was also assessed. The latency period for the development of moist desquamation in this model ranged from 4.00-6.75 weeks. There was no significant difference between the cream treatment and control sites. Application of Levosinum shortened the healing time of moist desquamation at each dose level by 5-10 days. In three out of four dose levels used, this shortening of the healing time was statistically significant (p < 0.03). Treatment with these topical applications also reduced the incidence of late dermal necrosis and increased the ED50 values for the incidence of dermal necrosis. This increase in ED50 values was equivalent to a dose modification factor of 1.11-1.13.
以猪皮为模型，研究两种局部应用乳膏Lipochromin和Levosinum对猪皮早期和晚期辐射损伤发展的改善效果。将暴露后每日局部应用Levosinum或Lipochromin的受照皮肤部位，与同一动物仅接受照射的对侧腹侧部位进行比较。采用分级剂量的90Sr/90Yβ射线进行照射。以湿性脱屑（急性）和缺血性皮肤坏死（晚期）的发生率作为终点指标。还评估了湿性脱屑发生的潜伏期及其愈合时间。该模型中湿性脱屑发生的潜伏期为4.00 - 6.75周。乳膏治疗部位与对照部位之间无显著差异。在每个剂量水平，应用Levosinum可使湿性脱屑的愈合时间缩短5 - 10天。在所使用的四个剂量水平中的三个，愈合时间的缩短具有统计学意义（p < 0.03）。这些局部应用治疗还降低了晚期皮肤坏死的发生率，并提高了皮肤坏死发生率的半数有效剂量（ED50）值。ED50值的这种增加相当于剂量修正系数为1.11 - 1.13。
