Yamaguchi K, Motegi K, Kurimoto M, Endo Y
Department of Oral and Maxillofacial Surgery (I), Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Okayama, Japan.
Inflamm Res. 2000 Oct;49(10):513-9. doi: 10.1007/s000110050624.
IL-18 shares functional properties with IL-12, which induces an elevation of histidine decarboxylase (HDC) activity in mouse tissues. Therefore, we examined the effects of IL-18 and IL-18+IL-12 on HDC activity.
IL-18, IL-12 or IL-18+IL-12 was intraperitoneally injected into BALB/c and C3H/HeN mice and their HDC activities were measured.
IL-18, at effective antitumour doses, induced HDC activity in lung, liver, spleen and bone. The IL-18-induced HDC elevation was more rapid than that induced by IL-12. As with IL-12, repeated injections of IL-18 produced more HDC activity than a single injection. Repeated injections of IL-18+IL-12 induced serious illness and produced marked HDC activity. However, an inhibitor of HDC did not prevent the illness.
IL-18 may be involved in the stimulation of histamine synthesis during the course of immune responses, though an elevation of HDC activity is not itself the direct cause of the serious illness induced by IL-18+IL-12.
白细胞介素-18（IL-18）与白细胞介素-12（IL-12）具有共同的功能特性，IL-12可使小鼠组织中的组氨酸脱羧酶（HDC）活性升高。因此，我们研究了IL-18和IL-18 + IL-12对HDC活性的影响。
将IL-18、IL-12或IL-18 + IL-12腹腔注射到BALB/c和C3H/HeN小鼠体内，并测定它们的HDC活性。
在有效的抗肿瘤剂量下，IL-18可诱导肺、肝、脾和骨骼中的HDC活性。IL-18诱导的HDC升高比IL-12诱导的更为迅速。与IL-12一样，重复注射IL-18比单次注射产生更多的HDC活性。重复注射IL-18 + IL-12会引发严重疾病并产生显著的HDC活性。然而，HDC抑制剂并不能预防这种疾病。
IL-18可能参与免疫反应过程中组胺合成的刺激，尽管HDC活性升高本身并非IL-18 + IL-12诱导严重疾病的直接原因。
