1型人类T细胞白血病病毒使T淋巴细胞永生化与Tax-CBP/p300相互作用无关。
Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the tax-CBP/p300 interaction.
作者信息
Robek M D, Ratner L
机构信息
Departments of Medicine, Pathology, and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
J Virol. 2000 Dec;74(24):11988-92. doi: 10.1128/jvi.74.24.11988-11992.2000.
Abstract
The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein is a 40-kDa nuclear phosphoprotein which functions in the viral replication cycle as a transcriptional trans-activator of the viral long terminal repeat. Tax interacts with a variety of different transcription factors, including the CREB binding protein (CBP)/p300 family of transcriptional accessory proteins. We demonstrate that a Tax mutant defective for the CBP/p300 interaction retains the capacity to immortalize primary human T lymphocytes when it is expressed from a functional molecular clone of HTLV-1. Thus, immortalization of HTLV-1-infected cells appears to be independent of Tax-induced alterations in CBP/p300 function.
摘要
人类1型T细胞白血病病毒（HTLV-1）的Tax癌蛋白是一种40 kDa的核磷蛋白，在病毒复制周期中作为病毒长末端重复序列的转录反式激活因子发挥作用。Tax与多种不同的转录因子相互作用，包括CREB结合蛋白（CBP）/p300转录辅助蛋白家族。我们证明，一个在与CBP/p300相互作用方面存在缺陷的Tax突变体，当它从HTLV-1的功能性分子克隆中表达时，仍保留使原代人T淋巴细胞永生化的能力。因此，HTLV-1感染细胞的永生化似乎独立于Tax诱导的CBP/p300功能改变。
相似文献
1
Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the tax-CBP/p300 interaction.1型人类T细胞白血病病毒使T淋巴细胞永生化与Tax-CBP/p300相互作用无关。
J Virol. 2000 Dec;74(24):11988-92. doi: 10.1128/jvi.74.24.11988-11992.2000.
2
Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.1型人类T细胞白血病病毒Tax突变体的差异性转录激活是由与CREB结合蛋白和p300的不同相互作用介导的。
Mol Cell Biol. 1998 Apr;18(4):2392-405. doi: 10.1128/MCB.18.4.2392.
3
Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity.p300的组蛋白乙酰转移酶（HAT）活性调节1型人类嗜T淋巴细胞病毒p30II介导的LTR转录活性抑制。
Virology. 2006 Oct 25;354(2):225-39. doi: 10.1016/j.virol.2006.07.002. Epub 2006 Aug 4.
4
Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template.p300介导的核小体组蛋白乙酰化促进了从人1型嗜T细胞白血病病毒（HTLV-1）的Tax反应性染色质模板的转录。
Mol Cell Biol. 2002 Jul;22(13):4450-62. doi: 10.1128/MCB.22.13.4450-4462.2002.
5
Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.通过在功能性分子克隆中表达的1型人类T细胞白血病病毒Tax突变体使CD4(+)和CD8(+) T淋巴细胞永生化。
J Virol. 1999 Jun;73(6):4856-65. doi: 10.1128/JVI.73.6.4856-4865.1999.
6
Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site.人类嗜T淋巴细胞病毒1型（HTLV-1）的Tax蛋白通过干扰CBP/p300与E-box或p53结合位点的DNA元件的结合，抑制CBP/p300介导的转录。
Oncogene. 1999 Jul 15;18(28):4137-43. doi: 10.1038/sj.onc.1202766.
7
Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control.人类T细胞白血病病毒Tax蛋白与共激活因子CBP的结合会干扰CBP介导的转录调控。
Oncogene. 1999 Jun 24;18(25):3766-72. doi: 10.1038/sj.onc.1202703.
8
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.人类I型T细胞白血病病毒癌蛋白Tax通过与CREB结合蛋白/p300相互作用抑制Smad依赖的转化生长因子β信号传导。
Blood. 2001 Apr 1;97(7):2137-44. doi: 10.1182/blood.v97.7.2137.
9
p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex.p300和p300/cAMP反应元件结合蛋白相关因子在多组蛋白乙酰转移酶/激活剂-增强子复合物中与人嗜T细胞病毒1型Tax相互作用。
J Biol Chem. 2000 Apr 21;275(16):11852-7. doi: 10.1074/jbc.275.16.11852.
10
Studies of the immortalizing activity of HTLV type 1 Tax, using an infectious molecular clone and transgenic mice.利用感染性分子克隆和转基因小鼠对1型人类嗜T淋巴细胞病毒（HTLV-1）Tax蛋白的永生化活性进行研究。
AIDS Res Hum Retroviruses. 2000 Nov 1;16(16):1647-51. doi: 10.1089/08892220050193092.
引用本文的文献
1
A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.一种新型的 HTLV-1 癌蛋白 Tax 与 T 细胞中 NF-κB 活性之间的正反馈环。
Retrovirology. 2020 Sep 10;17(1):30. doi: 10.1186/s12977-020-00538-w.
2
An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia.成人 T 细胞白血病中干扰素调节因子 4（IRF4）的激活突变。
J Biol Chem. 2018 May 4;293(18):6844-6858. doi: 10.1074/jbc.RA117.000164. Epub 2018 Mar 14.
3
FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma.FERM 结构域突变在成人 T 细胞白血病/淋巴瘤中诱导 JAK3 获得性功能。
Blood. 2011 Oct 6;118(14):3911-21. doi: 10.1182/blood-2010-12-319467. Epub 2011 Aug 5.
4
Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors.成像自发性肿瘤发生：炎症先于外周自然杀伤细胞肿瘤的发展。
Blood. 2009 Feb 12;113(7):1493-500. doi: 10.1182/blood-2008-07-166462. Epub 2008 Oct 29.
5
Construction and characterization of a full-length infectious simian T-cell lymphotropic virus type 3 molecular clone.全长感染性猿猴T细胞嗜淋巴病毒3型分子克隆的构建与鉴定
J Virol. 2007 Jun;81(12):6276-85. doi: 10.1128/JVI.02538-06. Epub 2007 Apr 11.
6
Human T-cell leukemia virus open reading frame II encodes a posttranscriptional repressor that is recruited at the level of transcription.人类T细胞白血病病毒开放阅读框II编码一种转录后阻遏物，该阻遏物在转录水平被招募。
J Virol. 2006 Jan;80(1):181-91. doi: 10.1128/JVI.80.1.181-191.2006.
7
Pathogenesis and treatment of human T-cell leukemia virus infection.人类T细胞白血病病毒感染的发病机制与治疗
Immunol Res. 2005;32(1-3):217-23. doi: 10.1385/IR:32:1-3:217.
8
Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13II sensitizes Jurkat T cells to Ras-mediated apoptosis.人嗜T淋巴细胞病毒1型线粒体定位蛋白p13II使Jurkat T细胞对Ras介导的凋亡敏感。
J Virol. 2005 Aug;79(15):9449-57. doi: 10.1128/JVI.79.15.9449-9457.2005.
9
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.Tax蛋白在I型人类T细胞白血病病毒致白血病性中的作用。
Retrovirology. 2004 Aug 13;1:20. doi: 10.1186/1742-4690-1-20.
10
Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein.人类1型T细胞白血病病毒Tax蛋白与细胞周期蛋白依赖性激酶4的物理相互作用刺激视网膜母细胞瘤蛋白的磷酸化。
Mol Cell Biol. 2002 May;22(10):3327-38. doi: 10.1128/MCB.22.10.3327-3338.2002.
本文引用的文献
1
p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex.p300和p300/cAMP反应元件结合蛋白相关因子在多组蛋白乙酰转移酶/激活剂-增强子复合物中与人嗜T细胞病毒1型Tax相互作用。
J Biol Chem. 2000 Apr 21;275(16):11852-7. doi: 10.1074/jbc.275.16.11852.
2
PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner.PCAF与Tax相互作用，并以一种不依赖组蛋白乙酰转移酶的方式刺激Tax反式激活。
Mol Cell Biol. 1999 Dec;19(12):8136-45. doi: 10.1128/MCB.19.12.8136.
3
Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis.p53与CREB结合蛋白的KIX结构域的结合。与I型人类T细胞白血病病毒相关白血病发生的潜在联系。
J Biol Chem. 1999 Sep 10;274(37):26321-8. doi: 10.1074/jbc.274.37.26321.
4
Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control.人类T细胞白血病病毒Tax蛋白与共激活因子CBP的结合会干扰CBP介导的转录调控。
Oncogene. 1999 Jun 24;18(25):3766-72. doi: 10.1038/sj.onc.1202703.
5
Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.通过在功能性分子克隆中表达的1型人类T细胞白血病病毒Tax突变体使CD4(+)和CD8(+) T淋巴细胞永生化。
J Virol. 1999 Jun;73(6):4856-65. doi: 10.1128/JVI.73.6.4856-4865.1999.
6
The coactivator CBP stimulates human T-cell lymphotrophic virus type I Tax transactivation in vitro.辅激活因子CBP在体外刺激I型人类嗜T细胞病毒Tax反式激活。
J Biol Chem. 1998 Dec 18;273(51):34646-52. doi: 10.1074/jbc.273.51.34646.
7
The human T-cell leukemia virus type 1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition for the CREB binding protein.人类1型T细胞白血病病毒癌蛋白Tax通过与CREB结合蛋白竞争来抑制c-Myb的转录活性。
J Virol. 1998 Nov;72(11):9396-9. doi: 10.1128/JVI.72.11.9396-9399.1998.
8
An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300.人类嗜T细胞病毒1型Tax蛋白中一个暴露的类KID结构域负责募集共激活因子CBP/p300。
Mol Cell Biol. 1998 Sep;18(9):5052-61. doi: 10.1128/MCB.18.9.5052.
9
Molecular interactions between the coactivator CBP and the human T-cell leukemia virus Tax protein.共激活因子CBP与人类T细胞白血病病毒Tax蛋白之间的分子相互作用。
J Mol Biol. 1998 Aug 21;281(3):395-400. doi: 10.1006/jmbi.1998.1951.
10
Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.1型人类T细胞白血病病毒Tax突变体的差异性转录激活是由与CREB结合蛋白和p300的不同相互作用介导的。
Mol Cell Biol. 1998 Apr;18(4):2392-405. doi: 10.1128/MCB.18.4.2392.
Zotero 插件