The prevalence of anergy in human immunodeficiency virus-infected adolescents and the association of delayed-type hypersensitivity with subject characteristics.

作者信息

Smith Rogers A, Ellenberg J H, Douglas S D, Henry-Reid L, Peralta L, Wilson C M

机构信息

Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA.

出版信息

J Adolesc Health. 2000 Dec;27(6):384-90. doi: 10.1016/s1054-139x(00)00161-0.

DOI:10.1016/s1054-139x(00)00161-0

PMID:11090740

Abstract

PURPOSE

To examine the prevalence of anergy in HIV-infected adolescents and factors associated with its occurrence.

METHODS

Anergy was defined as less than 2mm induration to each of three intradermally applied antigens (Candida albicans, tetanus toxoid, and mumps) between 24 and 96 hours in a population of HIV-infected adolescents aged 12-18 at entry in a national multicenter study of HIV disease progression. CD4(+) T-cell counts and plasma HIV-1 RNA were measured in quality controlled laboratories. Factors associated with the probability of anergy were examined with contingency table comparisons, tree-structured classification, and logistic regression analyses.

RESULTS

Overall prevalence of anergy in this clinic-based population of 167 was 11% [7% in males and 12% in females (p = 0.57)]. The sole significant predictor of anergy was decreased CD4(+) T-cell count (p = 0.005).

CONCLUSION

The prevalence of anergy is low in this HIV-infected population compared to older infected cohorts. The occurrence of differential rates of anergy in particular age and sex groupings that may be related to intrinsic immunologic differences requires further study.

摘要