De Gennaro L, Ferrara M, Bertini M
Dipartimento di Psicologia, Sezione di Neuroscienze, Università degli Studi di Roma 'La Sapienza' Via dei Marsi, 78, 00185, Roma, Italy.
Behav Brain Res. 2000 Nov 15;116(1):55-9. doi: 10.1016/s0166-4328(00)00247-3.
Spindle activity, visually scored in the 12-15 Hz range over antero-posterior midline derivations, has been assessed in ten normal subjects during a baseline and a recovery sleep after 2 nights of selective slow-wave sleep (SWS) deprivation. The recovery sleep, characterized by a significant increase of stage 4 and SWS as compared to the baseline, revealed that sleep spindles are reduced in the first NREM sleep cycle. The size of this reduction in spindle density progressively decreased in the course of the night, paralleling the depletion of SWS rebound. Topographical distribution of spindle activity showed a global linear increase over consecutive NREM-REM sleep cycles, regarding to the whole antero-posterior midline EEG derivations except the occipital one. It is concluded that the SWS rebound after 2 nights of selective SWS deprivation is associated with a reduction of spindles during stage 2.
在10名正常受试者中，通过视觉评分评估了前后中线导联上12 - 15赫兹范围内的纺锤波活动，这些受试者经历了2晚选择性慢波睡眠（SWS）剥夺后的基线睡眠和恢复睡眠。与基线相比，恢复睡眠的特征是4期和SWS显著增加，结果显示在第一个非快速眼动（NREM）睡眠周期中睡眠纺锤波减少。纺锤波密度的这种减少幅度在夜间逐渐减小，与SWS反弹的消耗情况平行。纺锤波活动的地形分布显示，在连续的NREM - REM睡眠周期中，除枕部导联外，整个前后中线脑电图导联上呈整体线性增加。得出的结论是，2晚选择性SWS剥夺后的SWS反弹与第2阶段纺锤波减少有关。
