Redila V A, Smith B R, Amit Z
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard, W., H-1013, H3G 1M8, Montreal, Quebec, Canada.
Alcohol. 2000 Jul;21(3):279-85. doi: 10.1016/s0741-8329(00)00096-3.
The present study was designed to investigate whether acetaldehyde shares stimulus properties with ethanol using the conditioned taste aversion (CTA) baseline of drug discrimination learning. Animals were trained to discriminate ethanol (0.8 g/kg, i.p.) from saline using 11 consecutive cycles consisting of a pairing day and three nonpairing days. On pairing days, all animals were injected with ethanol 30 min prior to a 20-min limited access to a saccharin solution (0.1% w/v) and then immediately injected with either LiCl (0.15 M, 1.8 meq) or distilled water. On the three following nonpairing days, animals were injected with saline and 30 min later presented with the same saccharin solution for 20 min. No injections followed on these nonpairing days. Results showed that animals acquired discriminative stimulus control for ethanol after seven pairings. Pretreatment with the catalase inhibitor did not alter the discriminative control for ethanol. Generalization tests revealed that acetaldehyde substituted for ethanol at a dose of 0.3 g/kg. The results of the present study suggest that catalase inhibition did not reverse or alter the discriminative stimulus effects of ethanol. However, generalization tests showed that acetaldehyde (0.3 g/kg) will substitute for ethanol suggesting that these two drugs share some similar properties.
本研究旨在利用药物辨别学习的条件性味觉厌恶（CTA）基线，研究乙醛是否与乙醇具有共同的刺激特性。动物接受训练，使用由一个配对日和三个非配对日组成的11个连续周期，从盐水中辨别乙醇（0.8 g/kg，腹腔注射）。在配对日，所有动物在有限接触糖精溶液（0.1% w/v）20分钟前30分钟注射乙醇，然后立即注射LiCl（0.15 M，1.8 meq）或蒸馏水。在接下来的三个非配对日，动物注射盐水，30分钟后给予相同的糖精溶液20分钟。在这些非配对日之后不进行注射。结果表明，动物在七次配对后获得了对乙醇的辨别性刺激控制。用过氧化氢酶抑制剂预处理并未改变对乙醇的辨别性控制。泛化试验表明，乙醛以0.3 g/kg的剂量替代乙醇。本研究结果表明，过氧化氢酶抑制并未逆转或改变乙醇的辨别性刺激作用。然而，泛化试验表明，乙醛（0.3 g/kg）将替代乙醇，表明这两种药物具有一些相似的特性。
