Liberti A, Loiacono L
D. Cotugno Hospital, Via E. Ponzio, 20-86170 Isernia, Naples, Italy.
Int J Antimicrob Agents. 2000 Nov;16(3):347-8. doi: 10.1016/s0924-8579(00)00262-4.
Strains of Salmonella typhi resistant to chloramphenicol and ampicillin have been isolated in several countries. This study compares treatment of Salmonella infection using ciprofloxacin (500 mg twice daily) for 10 days with chloramphenicol (50 mg/kg per day divided into four doses) for 14 days. The pathogen eradication rates for patients receiving ciprofloxacin was 18/20 (90%), compared with 25/28 (89%) for those who received chloramphenicol. Signs and symptoms in patients receiving chloramphenicol lasted longer and sometimes twice as long as patients treated with ciprofloxacin. In this study, ciprofloxacin was superior to cloramphenicol in the treatment of S. typhi infection and also had fewer side-effects and the convenience of a twice-a-day dosing
在几个国家已分离出对氯霉素和氨苄西林耐药的伤寒沙门氏菌菌株。本研究比较了使用环丙沙星（每日两次，每次500毫克）治疗10天与氯霉素（每日50毫克/千克，分四次给药）治疗14天对沙门氏菌感染的疗效。接受环丙沙星治疗的患者病原体根除率为18/20（90%），而接受氯霉素治疗的患者为25/28（89%）。接受氯霉素治疗的患者的体征和症状持续时间更长，有时是接受环丙沙星治疗患者的两倍。在本研究中，环丙沙星在治疗伤寒沙门氏菌感染方面优于氯霉素，且副作用更少，给药方便，每日两次。
