Bürger H, Poremba C, Diallo R, Dockhorn-Dworniczak B, Böcker W
Gerhard-Domagk-Institut für Pathologie, Westfälische Wilhelmsuniversität Münster.
Pathologe. 2000 Sep;21(5):375-82. doi: 10.1007/s002920000404.
Ductal carcinoma in situ of the female breast and lobular carcinoma in situ are regarded as precursor lesions of invasive breast cancer. We used comparative genomic hybridization to analyze the genetic relationship between these two types of lesion and invasive breast cancer. The series included 166 patients with ductal or lobular carcinoma in situ and invasive breast cancer. Our results reflect the broad heterogeneity of morphologically different subtypes of invasive and noninvasive breast cancer. The data also provide evidence of multiple genetic pathways of invasive breast cancer associated with different morphological subtypes. In conclusion, we propose a combined model of morphological-genetic progression with various parallel pathways in the pathogenesis of invasive breast cancer.
女性乳腺导管原位癌和小叶原位癌被视为浸润性乳腺癌的前驱病变。我们采用比较基因组杂交技术分析这两种病变与浸润性乳腺癌之间的遗传关系。该系列研究纳入了166例患有导管或小叶原位癌以及浸润性乳腺癌的患者。我们的结果反映了浸润性和非浸润性乳腺癌形态学不同亚型的广泛异质性。这些数据还为与不同形态学亚型相关的浸润性乳腺癌的多种遗传途径提供了证据。总之，我们提出了一种在浸润性乳腺癌发病机制中具有多种平行途径的形态学 - 遗传学进展联合模型。
